Slideshows Images Quizzes

Bicillin L-A Inj / Tubex

Last reviewed on RxList: 11/21/2016
Bicillin L-A Inj / Tubex Side Effects Center

Last reviewed on RxList 11/30/2016

Bicillin L-A (penicillin G benzathine) is an antibiotic used to treat or to prevent a variety of bacterial infections. Common side effects of Bicillin L-A include:

  • pain at the injection site,
  • nausea,
  • vomiting,
  • allergic reaction,
  • blurred vision,
  • dizziness, or
  • tired feeling.

Tell your doctor if you have serious side effects of Bicillin L-A including:

  • severe pain or peeling skin at injection site,
  • joint or muscle pain,
  • headache,
  • shortness of breath,
  • dizziness,
  • vision changes,
  • fast/slow/pounding heartbeat,
  • numbness or tingling of arms or legs,
  • pain/redness/swelling of arms or legs,
  • change in skin color near injection site or on arms or legs,
  • uncontrolled movements,
  • inability to move,
  • changes in the amount of urine,
  • new signs of infection (e.g., fever, persistent sore throat),
  • easy bruising or bleeding,
  • extreme tiredness,
  • dark or cloudy urine,
  • seizures, or
  • mental/mood changes (e.g., depression, agitation).

The recommended dosage of Bicillin L-A is based on the patient's weight and the infection being treated. It is administered by deep intramuscular injection only. Bicillin L-A may interact with blood thinners (for example Coumadin [warfarin]), bacterial vaccines, Rheumatrex, Trexall (methotrexate), NSAIDs, propenecid, tetracyclines, diuretics, and others. Tell your doctor all medications you use. Talk to your doctor if you are pregnant or plan on becoming pregnant during treatment. Consult your doctor before using Bicillin L-A if you are breastfeeding.

Our Bicillin L-A (penicillin G benzathine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Bicillin L-A Inj / Tubex Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • diarrhea that is watery or bloody;
  • fever, swollen glands, rash or itching, muscle or joint pain, night sweats, general ill feeling;
  • a feeling like you might pass out;
  • skin rash with bruising, severe tingling, numbness, pain, muscle weakness;
  • pale or yellowed skin, dark colored urine, weakness;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • little or no urinating;
  • fast or pounding heartbeats;
  • slow heart rate, weak pulse, fainting, slow breathing;
  • confusion, agitation, hallucinations, ringing in your ears, unusual thoughts or behavior;
  • seizure (convulsions);
  • pain, swelling, bruising, irritation, or skin changes where the injection was given; or
  • hardening of your skin in the thigh where the injection was given, trouble bending your knee.

Common side effects may include:

  • nausea, vomiting;
  • blurred vision;
  • dizziness; or
  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Bicillin L-A Inj / Tubex (Penicillin G Benzathine Injectable in Tubex)

Bicillin L-A Inj / Tubex Professional Information


As with other penicillins, untoward reactions of the sensitivity phenomena are likely to occur, particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with a history of allergy, asthma, hay fever, or urticaria.

As with other treatments for syphilis, the Jarisch-Herxheimer reaction has been reported.

The following have been reported with parenteral penicillin G:

General: Hypersensitivity reactions including the following: skin eruptions (maculopapular to exfoliative dermatitis), urticaria, laryngeal edema, fever, eosinophilia; other serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration); and anaphylaxis including shock and death. Note: Urticaria, other skin rashes, and serum sickness-like reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, penicillin G should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only to therapy with penicillin G. Serious anaphylactic reactions require immediate emergency treatment with epinephrine. Oxygen, intravenous steroids, and airway management, including intubation, should also be administered as indicated.

Gastrointestinal: Pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment. (See WARNINGS section.)

Hematologic: Hemolytic anemia, leukopenia, thrombocytopenia.

Neurologic: Neuropathy.

Urogenital: Nephropathy.

The following adverse events have been temporally associated with parenteral administration of penicillin G benzathine:

Body as a Whole: Hypersensitivity reactions including allergic vasculitis, pruritus, fatigue, asthenia, and pain; aggravation of existing disorder; headache.

Cardiovascular: Cardiac arrest; hypotension; tachycardia; palpitations; pulmonary hypertension; pulmonary embolism; vasodilation; vasovagal reaction; cerebrovascular accident; syncope.

Gastrointestinal: Nausea, vomiting; blood in stool; intestinal necrosis.

Hemic and Lymphatic: Lymphadenopathy.

Injection Site: Injection site reactions including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, and skin ulcer. Neurovascular reactions including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, and neurovascular damage.

Metabolic: Elevated BUN, creatinine, and SGOT.

Musculoskeletal: Joint disorder; periostitis; exacerbation of arthritis; myoglobinuria; rhabdomyolysis.

Nervous System: Nervousness; tremors; dizziness; somnolence; confusion; anxiety; euphoria; transverse myelitis; seizures; coma. A syndrome manifested by a variety of CNS symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne's syndrome), has been reported after administration of penicillin G procaine and, less commonly, after injection of the combination of penicillin G benzathine and penicillin G procaine. Other symptoms associated with this syndrome, such as psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and/or abnormal perception in taste, also may occur.

Respiratory: Hypoxia; apnea; dyspnea.

Skin: Diaphoresis.

Special Senses: Blurred vision; blindness.

Urogenital: Neurogenic bladder; hematuria; proteinuria; renal failure; impotence; priapism.

Read the entire FDA prescribing information for Bicillin L-A Inj / Tubex (Penicillin G Benzathine Injectable in Tubex)

Related Resources for Bicillin L-A Inj / Tubex

Read the Bicillin L-A Inj / Tubex User Reviews »

© Bicillin L-A Inj / Tubex Patient Information is supplied by Cerner Multum, Inc. and Bicillin L-A Inj / Tubex Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors