Last updated on RxList: 1/28/2021
Drug Description

What is Bionect and how is it used?

Bionect is a prescription medicine used to treat the symptoms of Osteoarthritis of Knee and Ophthalmic Viscoelastic Devices (OVDs). Bionect may be used alone or with other medications.

Bionect belongs to a class of drugs called Intra-Articular Agents; Ophthalmics, Other; Rhematologics, Other.

It is not known if Bionect is safe and effective in children.

What are the possible side effects of Bionect?

Bionect may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • redness, warmth of the skin,
  • pain, swelling of the skin, and
  • oozing or open sores

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Bionect include:

  • mild burning sensation in your mouth

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Bionect. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For topical use only


BIONECT® Cream is a white, viscous cream. BIONECT® Gel is a clear, colorless gel. The principal component is the sodium salt of hyaluronic acid (0.2%). Hyaluronic acid is a biological polysaccharide (glycosaminoglycan) and is a major component of the extracellular matrix of connective tissues.


BIONECT® Cream - Hyaluronic acid sodium salt (Hyalastine®), polyethyleneglycol 400 monostearate, decyl ester of oleic acid, emulsifying wax, glycerol, sorbitol solution 70%, sodium dehydroacetate, methylparaben, propylparaben, fragrance, purified water. BIONECT® Cel - Hyaluronic acid sodium salt, sorbitol solution 70%, sodium dehydroacetate, methylparaben, propylparaben, carbomer 980, sodium hydroxide, purified water.

Indications & Dosage


BIONECT® is indicated for the dressing and management of partial to full thickness dermal ulcers (pressure sores, venous stasis ulcers, arterial ulcers, diabetic ulcers), wounds including cuts, abrasions, donor sites, and post-operative incisions, irritations of the skin, and first and second degree burns. The dressing is intended to cover a wound or burn on a patient's skin, and protect against abrasion, friction, and desiccation.


The wounds or ulcers should be cleaned and disinfected prior to treatment. In the event of long-standing ulcers, it may be advisable to clean and/or to debride the wound by surgical or enzymatic means, prior to treatment. Apply a thin layer of BIONECT® without extensive rubbing onto the wound surface, two or three times per day. Cover the lesion area with a sterile gauze pad and, if necessary, with an elastic or compressive bandage.


BIONECT® Cream/Gel is supplied in a:

25g tube (Cream) - NDC 68712-007-02
30g tube (Gel) - NDC 68712-008-02
60g (2 - 30g Gel tubes) - NDC 68712-008-03


Please store BIONECT® at room temperature.
BIONECT® Cream may be stored for up to 24 months, BIONECT® Gel may be stored for up to 24 months.

Manufactured for: JSJ Pharmaceuticals, Inc. 140 East Bay Street, Charleston, SC 29401. Toll Free: 1-800-499-4468. Manufactured by: Fidia Farmaceutici S.p.A. Italy. July 2008


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Side Effects & Drug Interactions


All suspected adverse reactions occurring during the treatment with BIONECT® should be reported to your doctor.


Do not use concomitantly with disinfectants containing quaternary ammonium salts because hyaluronic acid can precipitate in their presence. The concomitant topical treatment of wounds with antibiotics or other local agents has never given rise to interactions or incompatibilities with BIONECT®.

Warnings & Precautions


If condition worsens, consult your physician immediately. Keep this product out of the reach of children. The prolonged use of the product may give rise to sensitization phenomena. Should this happen, discontinue the treatment and follow a suitable therapy. Do not use the product after the expiration date reported on the package.


Each tube of BIONECT® should be used by one patient only in order to reduce the risk of cross infection.

Overdosage & Contraindications


No information provided.


Do not administer to patients with known hypersensitivity to this product.

Clinical Pharmacology


No information provided.

Medication Guide


No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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