What Is Bisoprolol and How Does It Work?

Bisoprolol is a type of antihypertensive drug called a beta-adrenergic receptor blocking agent (beta-blocker) used to treat hypertension (high blood pressure).

Bisoprolol is available under the following different brand names: Monocor, and Zebeta.

What Are Dosages of Bisoprolol?

Dosages of Bisoprolol:

Dosage Forms and Strengths


  • 5 mg
  • 10 mg

Dosage Considerations – Should be Given as Follows:


  • Safety and efficacy not established


  • 2.5-5 mg orally once/day; may increase to 10 mg and if necessary to 20 mg orally once/day

Heart Failure

  • 1.25 mg orally once/day; increase gradually if necessary not to exceed 10 mg/day

Renal Impairment

  • Greater than 40 mL/min: Dose adjustment not necessary
  • Less than 40 mL/min: 2.5 mg/day initially; titrate slowly and monitor

What Are Side Effects Associated with Using Bisoprolol?

Common side effects of bisoprolol include:

Serious side effects of bisoprolol include:

  • Dizziness
  • Insomnia
  • Slow, irregular heartbeats
  • Upper respiratory infection
  • Diarrhea
  • Runny or stuffy nose
  • Joint pain
  • Cough
  • Shortness of breath
  • Nausea
  • Sore throat
  • Sinus infection (sinusitis)
  • Vomiting
  • Tiredness
  • Drowsiness
  • Lightheadedness upon standing
  • Spinning sensation (vertigo)
  • Dry mouth
  • Stomach pain
  • Constipation
  • Increased urination
  • Ringing in your ears
  • Weakness
  • Sleep problems (insomnia)
  • Anxiety
  • Restless feeling
  • Muscle pain
  • Itching or skin rash
  • Loss of interest in sex

Less common side effects of bisoprolol include:

Rare but serious side effects of bisoprolol include:

  • Very slow heartbeat
  • Severe dizziness
  • Fainting
  • Blue fingers/toes
  • Trouble breathing
  • Mental/mood changes (such as confusion, mood swings, depression)

Other side effects of bisoprolol include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Bisoprolol?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

Bisoprolol has no known severe interactions with other drugs.

Serious interactions of bisoprolol include:

Bisoprolol has moderate interactions with at least 173 different drugs.

Bisoprolol has mild interactions with at least 32 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine.

What Are Warnings and Precautions for Bisoprolol?


This medication contains bisoprolol. Do not take Monocor or Zebeta if you are allergic to bisoprolol or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


Effects of Drug Abuse

  • Avoid chronic use; may cause laxative dependence

Short-Term Effects

  • See "What Are Side Effects Associated with Using Bisoprolol?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Bisoprolol?"


Pregnancy and Lactation

  • Use bisoprolol with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.

From WebMD Logo

Heart Health Resources
Health Solutions From Our Sponsors
Medscape. Bisoprolol.
RxList. Zebeta Side Effects Drug Center.

Health Solutions From Our Sponsors