Black Mulberry

Reviewed on 6/11/2021
Other Name(s):

Morera Negra, Morus nigra, Mulberry, Mûrier Noir, Purple Mulberry.


Black mulberry is a plant. The ripe berry and root bark are used to make medicine.

Black mulberry is used as a laxative and to treat runny nose (rhinitis).

How does it work?

Black mulberry fruit contains pectin, which might act as a laxative to help stool pass through the bowels.


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Constipation.
  • Rhinitis (runny nose).
  • Other conditions.
More evidence is needed to rate the effectiveness of black mulberry for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

There isn't enough information to know whether or not black mulberry is safe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking black mulberry if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Allergies: People who are allergic to black mulberry might also be allergic to fig.

Diabetes: Black mulberry might lower blood sugar. If you have diabetes, monitor your blood sugar levels closely. The dose of your diabetes medication might need to be changed.

Surgery: Black mulberry seems to lower blood sugar levels. It might interfere with blood sugar control during and after surgery. Stop using black mulberry at least 2 weeks before a scheduled surgery.


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Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Some medications are changed and broken down by the liver. Black mulberry might slow down how quickly the liver breaks down some medications. Taking black mulberry along with some medications that are broken down by the liver might increase the effects and side effects of these medications. Before taking black mulberry, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Medications that might be affected include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others.

Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Black mulberry leaves might lower blood sugar. Diabetes medications are also used to lower blood sugar. Taking black mulberry leaves along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.


The appropriate dose of black mulberry for use as treatment depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for black mulberry. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Caiaffa, M. F., Cataldo, V. M., Tursi, A., and Macchia, L. Fig and mulberry cross-allergy. Ann.Allergy Asthma Immunol. 2003;91(5):493-495. View abstract.

de Souza, M. M., Bittar, M., Cechinel-Filho, V., Yunes, R. A., Messana, I., Delle, Monache F., and Ferrari, F. Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark. Z Naturforsch.[C.] 2000;55(3-4):256-260. View abstract.

Fu, D. X., Chen, L., Hou, A. J., Yao, Q., and Zhang, W. Y. Constituents of Morus nigra. Chinese Traditional and Herbal Drugs 2005;36

Kim, H., Yoon, Y. J., Shon, J. H., Cha, I. J., Shin, J. G., and Liu, K. H. Inhibitory effects of fruit juices on CYP3A activity. Drug Metab Dispos. 2006;34(4):521-523. View abstract.

Muntean, D., Imre, S., Avrigeanu, V., and Csedo, C. Physico-chemical study of the isolated flavonoids from leaves and bark of Morus alba L. and Morus nigra L. species. Farmacia 2002;50:97-103.

Naderi, G. A., Asgary, S., Sarraf-Zadegan, N., Oroojy, H., and Afshin-Nia, F. Antioxidant activity of three extracts of Morus nigra. Phytother.Res. 2004;18(5):365-369. View abstract.

Rabijns, A., Barre, A., Van Damme, E. J., Peumans, W. J., De Ranter, C. J., and Rouge, P. Structural analysis of the jacalin-related lectin MornigaM from the black mulberry (Morus nigra) in complex with mannose. FEBS J 2005;272(14):3725-3732. View abstract.

Rouge, P., Peumans, W. J., Barre, A., and Van Damme, E. J. A structural basis for the difference in specificity between the two jacalin-related lectins from mulberry (Morus nigra) bark. Biochem Biophys.Res Commun. 4-25-2003;304(1):91-97. View abstract.

Singh, T., Wu, J. H., Peumans, W. J., Rouge, P., Van Damme, E. J., and Wu, A. M. Recognition profile of Morus nigra agglutinin (Morniga G) expressed by monomeric ligands, simple clusters and mammalian polyvalent glycotopes. Mol Immunol. 3-30-2006. View abstract.

Wu, A. M., Wu, J. H., Singh, T., Chu, K. C., Peumans, W. J., Rouge, P., and Van Damme, E. J. A novel lectin (Morniga M) from mulberry (Morus nigra) bark recognizes oligomannosyl residues in N-glycans. J Biomed.Sci 2004;11(6):874-885. View abstract.

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