Blephamide Side Effects Center

Last updated on RxList: 11/17/2021
Blephamide Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Blephamide?

Blephamide (sulfacetamide sodium and prednisolone acetate ophthalmic ointment) is a topical ophthalmic ointment combining an antibacterial and a corticosteroid indicated for steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

What Are Side Effects of Blephamide?

Common side effects of Blephamide include:

Dosage for Blephamide

The dose of Blephamide is a small amount, approximately 1/2 inch ribbon of ointment, applied in the conjunctival sac three or four times daily and once or twice at night.

What Drugs, Substances, or Supplements Interact with Blephamide?

Blephamide may interact with silver preparations and local anesthetics. Tell your doctor all medications and supplements you use.

Blephamide During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Blephamide; it is unknown if it will affect a fetus. It is unknown if topically applied Blephamide passes into breast milk. Other forms of steroids pass into breast milk and may harm a nursing infant. Breastfeeding while using Blephamide is not recommended.

Additional Information

Our Blephamide (sulfacetamide sodium and prednisolone acetate ophthalmic ointment) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Blephamide Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • severe eye redness, eye pain, watery eyes, or sensitivity to light;
  • eye discomfort, crusting or drainage (may be signs of infection);
  • blurred vision, tunnel vision, seeing halos around lights;
  • small white or yellow patches on the surface of your eye;
  • pain behind your eyes, sudden vision changes; or
  • slow healing after eye surgery.

Stop using this medicine and talk to your doctor if you have new or worsening eye pain or swelling that lasts longer than 48 hours.

Common side effects may include:

  • eye redness, itching, or other irritation;
  • red or puffy eyelids;
  • blurred vision; or
  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Blephamide (Sulfacetamide Sodium and Prednisolone Acetate )


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Blephamide Professional Information


The following adverse reactions have been identified during use of BLEPHAMIDE® ophthalmic suspension. Because reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Adverse reactions have occurred with corticosteroid/antibacterial combination drugs which can be attributed to the corticosteroid component, the antibacterial component, or the combination.

Reactions occurring with BLEPHAMIDE® ophthalmic suspension include: cataract, dizziness, eye discharge, eyelid edema, eyelid erythema, eye irritation, eye pain, eye pruritus, and hypersensitivity including rash, skin pruritus, urticaria, ocular hyperemia, and visual disturbance (blurry vision).

Reactions occurring most often from the presence of the antibacterial ingredient are allergic sensitizations. Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias (see WARNINGS).

The reactions due to the corticosteroid component in decreasing order of frequency are: delayed wound healing, elevation of intraocular pressure (IOP) with possible development of glaucoma and infrequent optic nerve damage, and posterior subcapsular cataract formation.

Although systemic effects are extremely uncommon, there have been rare occurrences of systemic hypercorticoidism after use of topical corticosteroids.

Corticosteroid-containing preparations can also cause acute anterior uveitis or perforation of the globe. Mydriasis, loss of accommodation and ptosis have occasionally been reported following local use of corticosteroids.

Secondary Infection

The development of secondary infection has occurred after use of combinations containing corticosteroids and antibacterials. Fungal and viral infections of the cornea are particularly prone to develop coincidentally with long-term applications of corticosteroid. The possibility of fungal invasion must be considered in any persistent corneal ulceration where corticosteroid treatment has been used.

Secondary bacterial ocular infection following suppression of host responses also occurs.

Read the entire FDA prescribing information for Blephamide (Sulfacetamide Sodium and Prednisolone Acetate )

© Blephamide Patient Information is supplied by Cerner Multum, Inc. and Blephamide Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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