Boniva vs. Prolia

Are Boniva and Prolia the Same Thing?

Prolia (denosumab) and Boniva (ibandronate) are used to prevent and treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.

Prolia and Boniva belong to different drug classes. Prolia is a monoclonal antibody and Boniva is a bisphosphonate.

What Are Possible Side Effects of Boniva?

Common side effects of Boniva include:

What Are Possible Side Effects of Prolia?

Common side effects of Prolia include:

You may also be more likely to get a serious infection, such as a skin, ear, stomach/gut, or bladder infection while taking Prolia. Tell your doctor if you develop signs of infection, such as:

Tell your doctor if your experience serious side effects of Prolia including jaw pain, new or unusual thigh/hip/groin pain, or bone/joint/muscle pain.

What Is Boniva?

Boniva (ibandronate) is a bisphosphonate drug that alters the cycle of bone formation and breakdown in the body used to treat or prevent osteoporosis in women after menopause. Boniva slows bone loss while increasing bone mass, which may prevent bone fractures.

What Is Prolia?

Prolia (denosumab) is a monoclonal antibody used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.


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What Drugs Interact With Boniva?

Boniva may interact with aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs).

Boniva may also interact with products containing calcium, aluminum, magnesium, or iron (such as antacids, supplements or vitamins).

What Drugs Interact With Prolia?

Prolia may interact with steroids or cancer medicine, cyclosporine, sirolimus, tacrolimus, basiliximab, muromonab-CD3, mycophenolate mofetil, azathioprine, leflunomide, or etanercept.

How Should Boniva Be Taken?

Dosage of Boniva depends on the condition being treated.

How Should Prolia Be Taken?

The dose of Boniva is one 150 mg tablet taken once monthly on the same date each month.


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Genentech. Boniva Product Information.

Amgen. Prolia Product Information.

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