Botox vs. Restylane

Are Botox and Restylane the Same Thing?

Botox (onabotulinumtoxinA) and Restylane (hyaluronic acid) Dermal Filler Injectable Gel are both used to reduce facial wrinkles.

Botox is also used to treat chronic migraines, limb spasticity, axillary hyperhidrosis (sweaty underarms), cervical dystonia (severe muscle spasms in the neck), strabismus (crossed eyes), and blepharospasm (eyelid twitching).

Restylane Dermal Filler Injectable Gel is also used for mid-to-deep dermal implantation for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds (laugh lines), and for lip augmentation in patients over the age of 21.

Botox and Restylane belong to different drug classes and work in different way. Botox is an injectable neurotoxin that works by paralyzing the underlying muscles, and Restylane is a dermal filler that works by filling in the creases in the skin.

What Are Possible Side Effects of Botox?

Common side effects of Botox include:

Drooping of the eyelid (ptosis), inflammation of the cornea (keratitis), eye dryness, itchy eyes, double vision, eye irritation, tearing, increased sensitivity to light, reduced blinking, and eyelid swelling or bruising may occur when used for treating blepharospasm.

What Are Possible Side Effects of Restylane?

Common side effects of Restylane include:

  • swelling,
  • redness,
  • bruising,
  • tenderness,
  • itching, or
  • pain at the injection site

What is Botox?

Botox (onabotulinumtoxinA) is an injectable neuro-toxin used for the treatment of chronic migraines, limb spasticity, axillary hyperhidrosis, cervical dystonia, strabismus, and blepharospasm.

What is Restylane?

Restylane (hyaluronic acid) Dermal Filler Injectable Gel is used for mid-to-deep dermal implantation for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds (laugh lines). Restylane is also used for lip augmentation in patients over the age of 21.


Skin & Beauty: Anti-Aging Tips & Secrets to Look Younger See Slideshow

What Drugs Interact With Botox?

Administration of botulinum toxin with other agents (for example, aminoglycosides, curare) that affect neuromuscular function may increase the effect of botulinum toxin.

What Drugs Interact With Restylane?

Restylane may interact with other drugs. Tell your doctor all medications and supplements you use. Consult if you are pregnant, plan to become pregnant, or are breastfeeding before using Restylane.

How Should Botox Be Taken?

Botox is administered by injection and dosing depends on the condition that it is used for.

How Should Restylane Be Taken?

Dosing of Restylane depends on the area being treated and the severity of the wrinkles or folds.


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Allergan. Botox Cosmetic Product Monograph.

Galderma. Restylane Product Monograph.

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