Brilinta vs. Coumadin

Reviewed on 4/8/2021

Are Brilinta and Coumadin the Same Thing?

Brilinta (ticagrelor) and Coumadin (warfarin) are blood-thinners used to reduce cardiovascular death and heart attack in patients with acute coronary syndromes (ACS).

Side effects of Brilinta and Coumadin that are similar include bruising, bleeding more easily, and nausea.

Side effects of Brilinta that are different from Coumadin include nosebleeds, headache, dizziness, cough, diarrhea, irregular heartbeat, high blood pressure, back pain, low blood pressure, fatigue, and chest pain.

Side effects of Coumadin that are different from Brilinta include vomiting stomach pain, bloating, gas, and altered sense of taste.

Both Brilinta and Coumadin may interact with other medications to prevent blood clots, seizure medicines, antifungal medicines, and tuberculosis medicines.

Brilinta may also interact with antiviral medicines to treat HIV or AIDS, cholesterol medications, heart or blood pressure medications, and opioid medications.

Coumadin may also interact with antibiotics, sulfa drugs, antidepressants, herbal (botanical) products (including coenzyme Q10, cranberry, echinacea, garlic, ginkgo biloba, ginseng, goldenseal, or St. John's wort), secobarbital, and barbiturates.

What Are Possible Side Effects of Brilinta?

Common side effects of Brilinta are related to bleeding and include increased bleeding, nosebleeds, and bruising.

Other side effects of Brilinta include:

  • dizziness,
  • cough,
  • nausea,
  • diarrhea,
  • irregular heartbeat,
  • high or low blood pressure,
  • back pain,
  • fatigue, and
  • chest pain

What Are Possible Side Effects of Coumadin?

Common side effects of Coumadin include:

  • easy bruising and bleeding,
  • nausea, vomiting,
  • stomach pain,
  • bloating,
  • gas, or
  • altered sense of taste


Heart Disease: Symptoms, Signs, and Causes See Slideshow

What Is Brilinta?

Brilinta is a prescription medicine used to treat people who have had a heart attack or severe chest pain that happened because their heart was not getting enough oxygen.

Brilinta is used to lower your chance of having a heart attack or dying from a heart attack or stroke but Brilinta (and similar drugs) can cause bleeding that can be serious and sometimes lead to death.

What Is Coumadin?

Coumadin is prescription medicine used to treat blood clots and to lower the chance of blood clots forming in your body. Blood clots can cause a stroke, heart attack, or other serious conditions if they form in the legs or lungs.

It is not known if Coumadin is safe and effective in children.

What Drugs Interact With Brilinta?

Brilinta may interact with other blood thinners, HIV or AIDS medications, seizure medications, and antifungals. Brilinta may also interact with dexamethasone, digoxin, nefazodone, antibiotics, cholesterol-lowering medications, and heart or blood pressure medications.

Brilinta may also interact with dexamethasone (Decadron), digoxin (Lanoxin, Digitek, Digibind), nefazodone (Serzone), certain antibiotics, cholesterol-lowering medications (statins), and heart or blood pressure medications.

What Drugs Interact With Coumadin?

Coumadin may interact with antibiotics, St. John's wort, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), and antifungal medications.

Coumadin may also interact with other medications to prevent blood clots, sulfa drugs, medicines to treat tuberculosis, antidepressants, herbal (botanical) products (including coenzyme Q10, cranberry, echinacea, garlic, ginkgo biloba, ginseng, or goldenseal), secobarbital, barbiturates, and seizure medications.

How Should Brilinta be Taken?

Brilinta can be taken with or without food.

Brilinta is taken with aspirin. Talk to your doctor about the dose of aspirin that you should take with Brilinta. You should not take a dose of aspirin higher than 100 mg daily because it can affect how well Brilinta works. Do not take doses of aspirin higher than what your doctor tells you to take. Tell your doctor if you take other medicines that contain aspirin, and do not take new over-the-counter medicines with aspirin in them.

How Should Coumadin be Taken?

  • Take Coumadin exactly as prescribed. Your healthcare provider will adjust your dose from time to time depending on your response to Coumadin.
  • You must have regular blood tests and visits with your healthcare provider to monitor your condition.
  • If you miss a dose of Coumadin, call your healthcare provider. Take the dose as soon as possible on the same day. Do not take a double dose of Coumadin the next day to make up for a missed dose.
    • Call your healthcare provider right away if you:
    • take too much Coumadin
    • are sick with diarrhea, an infection, or have a fever
    • fall or injure yourself, especially if you hit your head. Your healthcare provider may need to check you


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

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FDA. Brilinta Drug Information.

FDA. Coumadin Drug Information.

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