Brintellix (Trintellix) vs. Pristiq

Are Brintellix (Trintellix) and Pristiq the Same Thing?

Brintellix (Trintellix) (vortioxetine) and Pristiq (desvenlafaxine) are antidepressants used to treat major depressive disorder (MDD).

Brintellix (Trintellix) is a selective serotonin reuptake inhibitor (SSRI) and Pristiq is a selective serotonin and norepinephrine reuptake inhibitor (SNRI).

What Are Possible Side Effects of Brintellix (Trintellix)?

Common side effects of Brintellix (Trintellix) include:

Antidepressants such as Brintellix (Trintellix) increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Tell your doctor if you experience any thoughts of suicide while taking Brintellix (Trintellix).

What Are Possible Side Effects of Pristiq?

Common side effects of Pristiq include:

What Is Brintellix (Trintellix)?

Brintellix (Trintellix) (vortioxetine) tablets are an antidepressant indicated for the treatment of major depressive disorder (MDD).

What Is Pristiq?

Pristiq (desvenlafaxine) is type of antidepressant called a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder.


Learn to Spot Depression: Symptoms, Warning Signs, Medication See Slideshow

What Drugs Interact With Brintellix (Trintellix)?

Brintellix (Trintellix) may interact with monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, buspirone, tramadol, tryptophan products, NSAIDs, aspirin, warfarin, bupropion, fluoxetine, paroxetine, quinidine, rifampicin, carbamazepine, and phenytoin. Tell your doctor all medications and supplements you use.

What Drugs Interact With Pristiq?

Pristiq may interact with cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, medicines for seizures or anxiety, other antidepressants, nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners, St. John's wort, tramadol, L-tryptophan, heart medications, or medicines to treat migraines.

Pristiq may also interact with diuretics (water pills), linezolid, lithium, metoclopramide, midazolam, antibiotics, antifungals, blood pressure medications, or HIV/AIDS medicines.

How Should Brintellix (Trintellix) Be Taken?

The recommended starting dose of Brintellix (Trintellix) is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated.

How Should Pristiq Be Taken?

The recommended dose for Pristiq is 50 mg once daily, with or without food.


Depression is a(n) __________ . See Answer

All drug information provided on is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, makes every effort to update its drug information. Due to the time-sensitive nature of drug information, makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the or websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.


Takeda Pharmaceuticals U.S.A., Inc. Trintellix Product Information
Pfizer. Pristiq Product Information.

Health Solutions From Our Sponsors