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Bullous Pemphigoid

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Bullous pemphigoid facts

  • Bullous pemphigoid is an autoimmune skin disease characterized by blisters.
  • The cause of bullous pemphigoid is not known.
  • Bullous pemphigoid can involve the lining of the mouth and nose.
  • The diagnosis of bullous pemphigoid is ultimately confirmed by biopsy.
  • Treatment of bullous pemphigoid is individualized and depends on the location and severity of the disease.

What is bullous pemphigoid?

Bullous pemphigoid is an uncommon skin disease characterized by tense blisters on the surface of the skin. Occasionally, the inner lining tissue of the mouth, nasal passages, or conjunctivae of the eyes (mucous membrane tissue) can be involved. The condition is caused by antibodies and inflammation abnormally accumulating in a particular layer of the skin or mucous membranes. This layer of tissue is called the "basement membrane." These antibodies (immunoglobulins) bind to proteins in the basement membrane called hemidesmosomal BP antigens and this attracts cells of inflammation. The mucous membrane disease is also referred to separately as mucous membrane pemphigoid.

Medically Reviewed by a Doctor on 8/31/2016


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