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Bumex

Last reviewed on RxList: 8/10/2020
Bumex Side Effects Center

What Is Bumex?

Bumex (bumetanide) is a loop diuretic (water pill) that prevents the body from absorbing too much salt, allowing the salt to instead be passed in the urine, used to treat fluid retention (edema) in people with high blood pressure, congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome. Bumex is available in generic form.

What Are Side Effects of Bumex?

Common side effects of Bumex include:

  • dizziness,
  • skin rash or itching, or
  • headache as your body adjusts to the medication.

Tell your doctor if you experience side effects of Bumex including:

  • muscle cramps or pain,
  • weakness,
  • tiredness,
  • confusion,
  • dizziness,
  • lightheadedness,
  • fainting,
  • drowsiness,
  • dry mouth/thirst,
  • stomach pain,
  • nausea,
  • vomiting,
  • fast/irregular heartbeat,
  • an unusual decrease in the amount of urine as these may be signs of severe dehydration,
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling),
  • trouble concentrating,
  • memory problems,
  • loss of appetite,
  • feeling unsteady,
  • hallucinations,
  • seizures,
  • shallow breathing or breathing that stops,
  • easy bruising,
  • unusual bleeding (nose, mouth, vagina, or rectum),
  • purple or red pinpoint spots under your skin,
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash, or
  • hearing problems.

Dosage for Bumex

The usual daily dosage of Bumex is 0.5 mg to 2 mg and in most patients is given as a single dose.

What Drugs, Substances, or Supplements Interact with Bumex?

Products that may interact with this drug include indomethacin, lithium, probenecid, and other drugs that can affect your hearing (including aminoglycoside antibiotics such as gentamicin, tobramycin). If you have diabetes, Bumex may affect your blood sugar level.

Bumex During Pregnancy and Breastfeeding

Bumex may also reduce the potassium level in your blood. During pregnancy, this drug should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Bumex Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

About how much does an adult human brain weigh? See Answer
Bumex Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • hearing problems;
  • confusion, hallucinations, problems with thought or memory;
  • trouble speaking or understanding what is said to you;
  • unusual weakness;
  • twitching, or a seizure;
  • weak or shallow breathing;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • low magnesium--dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling;
  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or
  • dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Common side effects may include:

  • muscle cramps;
  • dizziness;
  • low blood presure;
  • nausea; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Bumex (Bumetanide)

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Bumex Professional Information

SIDE EFFECTS

The most frequent clinical adverse reactions considered probably or possibly related to Bumex are muscle cramps (seen in 1.1% of treated patients), dizziness (1.1%), hypotension (0.8%), headache (0.6%), nausea (0.6%) and encephalopathy (in patients with preexisting liver disease) (0.6%). One or more of these adverse reactions have been reported in approximately 4.1% of patients treated with Bumex.

Serious skin reactions (i.e., Stevens-Johnson syndrome, toxic epidermal necrolysis) have been reported in association with bumetanide use.

Less frequent clinical adverse reactions to Bumex are impaired hearing (0.5%), pruritus (0.4%), electrocardiogram changes (0.4%), weakness (0.2%), hives (0.2%), abdominal pain (0.2%), arthritic pain (0.2%), musculoskeletal pain (0.2%), rash (0.2%) and vomiting (0.2%). One or more of these adverse reactions have been reported in approximately 2.9% of patients treated with Bumex.

Other clinical adverse reactions, which have each occurred in approximately 0.1% of patients, are vertigo, chest pain, ear discomfort, fatigue, dehydration, sweating, hyperventilation, dry mouth, upset stomach, renal failure, asterixis, itching, nipple tenderness, diarrhea, premature ejaculation and difficulty maintaining an erection.

Laboratory abnormalities reported have included hyperuricemia (in 18.4% of patients tested), hypochloremia (14.9%), hypokalemia (14.7%), azotemia (10.6%), hyponatremia (9.2%), increased serum creatinine (7.4%), hyperglycemia (6.6%), and variations in phosphorus (4.5%), CO content (4.3%), bicarbonate (3.1%) and calcium (2.4%). Although manifestations of the pharmacologic action of Bumex, these conditions may become more pronounced by intensive therapy.

Also reported have been thrombocytopenia (0.2%) and deviations in hemoglobin (0.8%), prothrombin time (0.8%), hematocrit (0.6%), WBC (0.3%) and differential counts (0.1%). There have been rare spontaneous reports of thrombocytopenia from postmarketing experience.

Diuresis induced by Bumex may also rarely be accompanied by changes in LDH (1.0%), total serum bilirubin (0.8%), serum proteins (0.7%), SGOT (0.6%), SGPT (0.5%), alkaline phosphatase (0.4%), cholesterol (0.4%) and creatinine clearance (0.3%). Increases in urinary glucose (0.7%) and urinary protein (0.3%) have also been seen.

To report SUSPECTED ADVERSE REACTIONS, contact Validus Pharmaceuticals, LLC at 1-866-982-5438 (1-866-9VALIDUS) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Read the entire FDA prescribing information for Bumex (Bumetanide)

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