Buprenex vs. Nubain

Are Buprenex and Nubain the Same Thing?

Buprenex (buprenorphine hydrochloride) and Nubain (nalbuphine hydrochloride) are narcotics indicated for the relief of moderate to severe pain.

Nubain is also used for treating pain just after surgery or childbirth.

What Are Possible Side Effects of Buprenex?

Common side effects of Buprenex include:

Tell your doctor if you have serious side effects of Buprenex including:

  • weak or shallow breathing,
  • lightheadedness,
  • fainting,
  • blue lips or fingernails,
  • confusion,
  • feelings of extreme happiness,
  • fast or slow heart rate, or
  • urinating less than usual or not at all.

What Are Possible Side Effects of Nubain?

Common side effects of Nubain include:

  • flushing (warmth, tingling, or redness),
  • nausea,
  • vomiting,
  • stomach cramps or pain,
  • upset stomach,
  • dizziness,
  • spinning sensation,
  • dry mouth,
  • bitter or unpleasant taste in your mouth,
  • sweating,
  • skin itching or burning sensation,
  • rash,
  • headache,
  • nervousness,
  • restlessness,
  • depression,
  • strange dreams,
  • slurred speech, or
  • blurred vision.

What Is Buprenex?

Buprenex (buprenorphine hydrochloride) injectable is a narcotic drug indicated for the relief of moderate to severe pain.

What Is Nubain?

Nubain (nalbuphine hydrochloride) is a narcotic pain reliever used to treat moderate to severe pain. Nubain is also used for treating pain just after surgery or childbirth.


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What Drugs Interact With Buprenex?

Buprenex may interact with alcohol, other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, other medicines that can make you sleepy or slow your breathing, dexamethasone, imatinib, isoniazid, nefazodone, St. John's wort, antibiotics, antifungal medications, barbiturates, blood thinners, heart or blood pressure medications, HIV/AIDS medicines, MAO inhibitors, medicines to treat narcolepsy, phenothiazines, or seizure medications. Tell your doctor all medications and supplements you use.

What Drugs Interact With Nubain?

Nubain may interact with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or any other medicines that can make you sleepy or slow your breathing. Tell your doctor all medications you use.

How Should Buprenex Be Taken?

The usual dosage for persons 13 years of age and over is 1 ml Buprenex given by deep intramuscular or slow (over at least 2 minutes) intravenous injection at up to 6-hour intervals, as needed.

How Should Nubain Be Taken?

The usual recommended adult dose of Nubain is 10 mg for a 70 kg individual, administered subcutaneously, intramuscularly or intravenously; this dose may be repeated every 3 to 6 hours as necessary.


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DailyMed. Buprenex Product Information.
DailyMed. Nubain Product Information.

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