What Is Burkitt Lymphoma?

Reviewed on 7/29/2021

There are multiple types of Burkitt lymphoma. Burkitt lymphomas are types of non-Hodgkin's lymphoma that affect the bone marrow and central nervous system. Symptoms of Burkitt lymphoma may include nausea, vomiting, headache, fatigue, enlarged lymph nodes, and many other symptoms.
There are multiple types of Burkitt lymphoma. Burkitt lymphomas are types of non-Hodgkin's lymphoma that affect the bone marrow and central nervous system. Symptoms of Burkitt lymphoma may include nausea, vomiting, headache, fatigue, enlarged lymph nodes, and many other symptoms.

Burkitt lymphomas are aggressive B-cell cancers (non-Hodgkin type of lymphomas) that frequently involve aggressive progression in the bone marrow and in the central nervous system. Burkitt lymphoma (also known as small non-cleaved cell lymphoma and Burkitt's lymphoma) has a variant termed Burkitt-like lymphoma or BLL. Other types of Burkitt lymphoma are termed as follows:

The WHO (World Health Organization) suggests that there is little difference between Burkitt lymphoma and BLL and considers them essentially the same disease. The other variants are classified under the term Burkitt lymphoma. For the purposes of this article, we will discuss only Burkitt lymphoma and will not discuss small differences in subtypes. Because of their rapid progression, these lymphomas are considered medical emergencies that require fast diagnosis and treatment.

Burkitt lymphomas comprise about 1%-2% of all lymphomas. The African variety usually starts as a jaw tumor while in United States, they usually begin as an abdominal tumor. About 90% of these lymphomas occur in males. In Africa, they occur mainly in children while in United States, the average age of onset is 30 years.

What causes Burkitt lymphoma?

What are the symptoms and signs of Burkitt lymphoma?

Signs and symptoms of Burkitt lymphoma are somewhat similar in all types and may include the following:

Abdominal symptoms are more prominent with Burkitt lymphoma seen in the U.S., while endemic (African) Burkitt lymphoma tends to cause more jaw-related symptoms.

How do health care professionals diagnose Burkitt lymphoma?

  • Diagnosis of Burkitt lymphoma depends upon pathologic evaluation of the involved tissue; consequently a bone marrow biopsy or aspiration is sometimes required and/or a tissue sample (for example, lymph node biopsy or a jaw tissue mass biopsy is done.).
  • In addition to the biopsy, laboratory testing is usually done, and imaging studies such as CT scanning and echocardiography help determine the extent of the disease. Other procedures or studies that may be performed are removal of fluid collections in the abdomen or thorax for cytogenetic evaluation.

How do physicians determine the staging of Burkitt lymphoma?

The stage of a tumor is the extent to which it has spread in the body. Unfortunately, different researchers have different ways of staging Burkitt lymphoma. The National Cancer Institute has a five stage system and is as follows:

  • A: Single solitary extra-abdominal site
  • AR: Intra-abdominal, more than 90% of tumor resected
  • B: Multiple extra-abdominal tumors
  • C: Intra-abdominal tumor
  • D: Intra-abdominal plus 1 or more extra-abdominal sites

The Michigan Ann Arbor system and St. Jude/Murphy system uses the following stages:

  • Stage I: Single tumor (extranodal or outside a lymph node) or single anatomic area
  • Stage II: Single tumor (extranodal) with regional node involved, primary gastrointestinal tumor and/or lymphoma involving nodal areas on the same side of the diaphragm
  • Stage IIR: Completely resected intra-abdominal disease
  • Stage III: Lymphoma involving sites on opposite sides of the diaphragm, all primary intrathoracic tumors, all paraspinal or epidural tumors, and/or extensive intra-abdominal disease

Patients should discuss which staging system their doctors use.

What is the treatment for Burkitt lymphoma?

What is the prognosis for patients with Burkitt lymphoma?

  • The prognosis for about 90% of pediatric patients and up to 50%-60% of adults is good, with long-term survival expected if the patient is quickly diagnosed and treated appropriately with chemotherapy. The prognosis for adults is more guarded (see survival rate section below).

What are the survival rates for patients with Burkitt lymphoma?

  • Adults usually do not do as well as children, especially if they have bone marrow involvement; cytogenetics of adult cells is more complex, resulting in aggressive disease.
  • Survival for children can be as high as 90% as compared to about 50%-60% for adults.
  • For adults with low-risk disease, the five-year survival rate is about 71%, while high-risk aggressive lymphomas have about a 29% five-year survival rate.
  • The survival rate decreases as the patient's age increases.

What is the follow-up care for Burkitt lymphoma?

  • Patients who undergo chemotherapy may develop complications such as tumor lysis syndrome, renal failure, heart problems, infections, sterility, or other cancers.
  • Consequently, patients need continual follow-up care to monitor for any complications that may develop, including recurrence of their lymphoma.

Health Solutions From Our Sponsors

References
Kanbar, A. H., et al. "Burkitt Lymphoma and Burkitt-like Lymphoma." Medscape. Apr. 8, 2016. <https://emedicine.medscape.com/article/1447602-overview>.

"Types of Non-Hodgkin Lymphoma." American Cancer Society. Aug. 26, 2014.

Health Solutions From Our Sponsors