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Butterbur

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Are there any interactions with medications?



Medications that increase breakdown of other medications by the liver (Cytochrome P450 3A4 (CYP3A4) inducers)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Butterbur is broken down by the liver. Some chemicals that form when the liver breaks down butterbur can be harmful. Medications that cause the liver to break down butterbur might enhance the toxic effects of chemicals contained in butterbur.

Some of these medicines include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Dosing considerations for Butterbur.

The following doses have been studied in scientific research:

ADULT:

BY MOUTH:
  • For hay fever (allergic rhinitis): Up to 6 tablets of a specific butterbur leaf extract called Ze 339 (Tesalin, Zeller AG), has been taken daily in up to three divided doses for 1-2 weeks. 50 mg of a specific whole butterbur root extract (Petaforce, Bioforce) has been taken twice daily for 2 weeks.
  • For migraine headache: 75-150 mg of a specific butterbur rhizome extract (Petadolex, Weber & Weber, GmbH & Co, Germany) has been taken daily in up to two divided doses for up to 4 months.
  • For mental illnesses that cause physical pain (somatoform disorders): A specific product called Ze185 (Relaxane, Max Zeller Söhne AG, Switzerland) containing 90 mg of dry extracts of butterbur root, 90 mg of valerian root, 90 mg of passionflower herb, and 60 mg of lemon balm leaf, has been taken three times daily for 2 weeks.
CHILDREN:

BY MOUTH:
  • For migraine headache: 50-75 mg of a specific butterbur rhizome extract (Petadolex, Weber & Weber, GmbH & Co, Germany) has been taken daily in two or three divided doses for children 8-9 years-old, and in doses of 100-150 mg daily in two or three divided doses for children 10-17 years-old, for up to 4 months.

Therapeutic Research Faculty copyright

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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