Cafergot

Last updated on RxList: 07/12/2021
Cafergot Patient Information Including Side Effects

Brand Names: Cafatine, Cafergot, Cafetrate, Ercaf, Migergot, Wigraine

Generic Name: caffeine and ergotamine (oral/rectal)

What is caffeine and ergotamine?

Caffeine is a stimulant that causes narrowing of blood vessels (vasoconstriction). Ergotamine is an ergot alkaloid (ER-got AL-ka-loid) that works by narrowing blood vessels around the brain.

Caffeine and ergotamine is a combination medicine used to treat or prevent a migraine type headache.

This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.

Caffeine and ergotamine should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.

Caffeine and ergotamine may also be used for purposes not listed in this medication guide.

What are the possible side effects of caffeine and ergotamine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using caffeine and ergotamine and call your doctor at once if you have:

  • severe pain in your stomach or back;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • cramps in your hips or legs, leg pain or swelling;
  • weak pulses in your arms and legs, numbness and tingling or pain in your hands or feet, blue-colored fingers or toes;
  • muscle pain or weakness in your arms or legs;
  • fast or slow heart rate;
  • severe headache, blurred vision, pounding in your neck or ears;
  • sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or
  • painful sores on your rectum after using the rectal suppositories.

Serious side effects are more likely with overuse of caffeine and ergotamine. This medicine is not for daily use.

Common side effects may include:

  • numbness, tingling, burning pain;
  • dizziness, spinning sensation;
  • weakness;
  • itching or swelling;
  • nausea, vomiting; or
  • (with suppository use) a rectal sore or ulcer.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about caffeine and ergotamine?

Some medicines can cause a dangerous decrease in blood flow when used with caffeine and ergotamine. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects.

You should not use this medicine if you have coronary heart disease, high blood pressure, circulation problems, liver or kidney disease, or sepsis.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Do not use if you are pregnant or could become pregnant.

SLIDESHOW

16 Surprising Headache Triggers and Tips for Pain Relief See Slideshow
Cafergot Patient Information including How Should I Take

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What should I discuss with my healthcare provider before using caffeine and ergotamine ?

You should not use this medicine if you are allergic to caffeine or ergotamine, or if you have:

  • coronary heart disease;
  • high blood pressure;
  • blood circulation problems;
  • sepsis (a severe reaction to an infection);
  • liver disease;
  • kidney disease; or
  • if you are pregnant or could become pregnant.

Many drugs can cause a dangerous decrease in blood flow when used with caffeine and ergotamine. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects. Some drugs should not be used together with caffeine and ergotamine. Your doctor may change your treatment plan if you also use:

  • zileuton;
  • an antidepressant--fluoxetine, fluvoxamine, nefazodone;
  • an antibiotic--clarithromycin, erythromycin, metronidazole, telithromycin;
  • antifungal medicine--clotrimazole, fluconazole, itraconazole, ketoconazole; or
  • antiviral medicine to treat HIV/AIDS--indinavir, nelfinavir, ritonavir, saquinavir.

Do not use caffeine and ergotamine if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and tell your doctor if you become pregnant.

You should not breastfeed while using this medicine.

How should I use caffeine and ergotamine?

Follow all directions on your prescription label. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. This medicine is not for daily use.

To use caffeine and ergotamine tablets:

  • Take 2 tablets of caffeine and ergotamine as soon as you notice headache symptoms, or after an attack has already begun.
  • If your headache does not completely go away, you may take 1 more tablet after at least 30 minutes have passed.
  • If additional medication is needed, you may take 1 tablet every 30 minutes up to a total of 6 tablets for one migraine attack.

If you still have migraine symptoms after taking a total of 6 tablets, call your doctor. Do not take more than a total of 6 tablets in any 24-hour period. Do not take more than a total of 10 tablets over a period of 7 days.

Do not take a rectal suppository by mouth. It is for use only in your rectum.

Wash your hands before and after inserting the suppository.

To use caffeine and ergotamine rectal suppositories:

  • Insert 1 suppository at the first sign of migraine headache symptoms, or after an attack has already begun.
  • Remove the wrapper before inserting the suppository. Avoid handling the suppository too long or it will melt.
  • Lie on your back with your knees up toward your chest. Gently insert the suppository into your rectum about 1 inch, pointed tip first.
  • Stay lying down for a few minutes while the suppository melts. You should feel little or no discomfort. Avoid using the bathroom for at least an hour.
  • If your headache does not completely go away, use 1 more suppository after at least 1 hour has passed.

If you still have migraine symptoms after using a total of 2 rectal suppositories, call your doctor. Do not use more than a total of 2 suppositories per headache. Do not use more than a total of 5 suppositories over a period of 7 days.

Do not share this medication with another person, even if they have the same symptoms you have.

Store tablets at room temperature away from moisture, heat, and light.

Store rectal suppositories in the refrigerator, do not freeze.

QUESTION

Who suffers more frequently from migraine headaches? See Answer
Cafergot Patient Information including If I Miss a Dose

What happens if I miss a dose?

Since caffeine and ergotamine is used only when needed, you are not likely to miss a dose.

Do not take more than 6 caffeine and ergotamine tablets per day or more than 10 tablets per week.

Do not use more than 2 suppositories per headache or 5 suppositories per week.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of caffeine and ergotamine can be fatal.

Overdose symptoms may include vomiting, blurred vision, pounding in your neck or ears, feeling drowsy or light-headed, seizure, or signs of decreased blood flow in your arms or legs (pain, numbness, tingling, weak pulses, or a blue appearance).

What should I avoid while using caffeine and ergotamine?

Do not use caffeine and ergotamine within 24 hours before or after using another migraine headache medicine, including:

Grapefruit and grapefruit juice may interact with caffeine and ergotamine and lead to unwanted side effects. Avoid the use of grapefruit products while taking caffeine and ergotamine.

What other drugs will affect caffeine and ergotamine?

Tell your doctor about all your current medicines. Many drugs can affect caffeine and ergotamine, especially:

This list is not complete and many other drugs may affect caffeine and ergotamine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about caffeine and ergotamine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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