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Calcium Channel Blockers (CCBs)

For what conditions are calcium channel blockers used?

Calcium channel blockers are approved for treating:

They are also used for treating other conditions such as:

Are there any differences among calcium channel blockers?

Although calcium channel blockers have a similar mechanism of action, they differ in their ability to affect heart muscle vs. arteries, and they differ in their ability to affect heart rate and contraction. These differences determine how they are used and their side effects.

For example:

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What are the side effects of calcium channel blockers?

Common side effects of calcium channel blockers include:

Sexual dysfunction, overgrowth of gums, and liver dysfunction also have been associated with calcium channel blockers. Verapamil (Covera-HS, Verelan PM, Calan) and diltiazem (Cardizem LA, Tiazac) worsen heart failure because they reduce the ability of the heart to contract and pump blood.

With which drugs do calcium channel blockers interact?

Calcium channel blockers interact with several drugs.

What are some examples of calcium channel blockers available?

The calcium channel blockers available in the U. S. are:

  • amlodipine (Norvasc),
  • diltiazem (Cardizem LA, Tiazac),
  • felodipine (Plendil),
  • isradipine (Dynacirc),
  • nifedipine (Adalat, Procardia),
  • nicardipine (Cardene),
  • nimodipine (Nimotop),
  • nisoldipine (Sular), and
  • verapamil (Covera-HS, Verelan PM, Calan).

Verapamil, diltiazem and nicardipine (Cardene IV) also are available in intravenous formulations.

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

What are some examples of calcium channel blockers available?

The calcium channel blockers available in the U. S. are:

  • amlodipine (Norvasc),
  • diltiazem (Cardizem LA, Tiazac),
  • felodipine (Plendil),
  • isradipine (Dynacirc),
  • nifedipine (Adalat, Procardia),
  • nicardipine (Cardene),
  • nimodipine (Nimotop),
  • nisoldipine (Sular), and
  • verapamil (Covera-HS, Verelan PM, Calan).

Verapamil, diltiazem and nicardipine (Cardene IV) also are available in intravenous formulations.

References
Reviewed by:
Robert J. Bryg, MD
Board Certified Internal Medicine with subspecialty in Cardiovascular Disease
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