Calcium D-Glucarate

Reviewed on 6/11/2021
Other Name(s):

Calcio D-Glucarato, Calcium Glucarate, Calcium-D Glucarate, Calcium-D-Glucarate, D-Glucarate (GA), D-glucaro-1,4-lactone (1,4 GL), Glucarate de Calcium.


Calcium D-glucarate is a chemical. It is similar to a naturally occurring chemical called glucaric acid. Glucaric acid is found in our bodies as well as in fruits and vegetables such as oranges, apples, brussels sprouts, broccoli, and cabbage. Calcium D-glucarate is made by combining glucaric acid with calcium to make supplements that people use for medicine.

Calcium D-glucarate is used for preventing breast, prostate, and colon cancer; and for removing cancer-causing agents, toxins, and steroid hormones from the body.

How does it work?

Calcium D-glucarate might lower estrogen levels, and this is thought to be helpful in treating some people with hormone-dependent cancers. There isn't enough evidence to support the use of calcium D-glucarate for preventing cancer in humans.


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Preventing breast, prostate, and colon cancer.
  • Detoxifying the body by removing carcinogens, toxins, and steroid hormones.
  • Other conditions.
More evidence is needed to rate the effectiveness of calcium D-glucarate for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

There isn't not enough information to know if calcium D-glucarate is safe or what the potential side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of calcium D-glucarate during pregnancy and breast-feeding. Stay on the safe side and avoid use.


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Alcohol (Ethanol)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

The body breaks down calcium D-glucarate to get rid of it. Alcohol might increase how fast the body gets rid of calcium D-glucarate. By increasing how fast the body gets rid of calcium D-glucarate, alcohol might decrease the effectiveness of calcium D-glucarate.

Medications changed by the liver (Glucuronidated drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

The body breaks down some medications to get rid of them. The liver helps break down these medications. Calcium D-glucarate might increase how quickly some medications are broken down by the liver. Taking calcium-D glucarate along with medications changed by the liver might decrease the effectiveness of these medications.

Some of these medications changed by the liver include acetaminophen (Tylenol, others), atorvastatin (Lipitor), diazepam (Valium), digoxin, entacapone (Comtan), estrogen, irinotecan (Camptosar), lamotrigine (Lamictal), lorazepam (Ativan), lovastatin (Mevacor), meprobamate, morphine, oxazepam (Serax), and others.

KanamycinInteraction Rating: Minor Be cautious with this combination.Talk with your health provider.

Kanamycin is an antibiotic. The body breaks down kanamycin to get rid of it. Calcium D-glucarate might increase how quickly the body gets rid of kanamycin. Taking calcium-D-glucarate along with kanamycin might decrease the effectiveness of kanamycin.


The appropriate dose of calcium D-glucarate depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for calcium D-glucarate. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Curley RW Jr, Humphries KA, Koolemans-Beynan A, et al. Activity of D-glucarate analogues: synergistic antiproliferative effects with retinoid in cultured human mammary tumor cells appear to specifically require the D-glucarate structure. Life Sci 1994;54:1299-303. View abstract.

Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on B-glucuronidase activity and glucarate content on certain vegetables and fruits. Biochem Med Metab Bio 1990;43:83-92. View abstract.

Furuno K, Matsubara S, Ando K, Suzuki S. Preventive effect of D-glucarate against renal damage induced by kanamycin. J Antibiot (Tokyo) 1976;29:950-3. View abstract.

Heerdt AS, Young CW, Borgen PI. Calcium glucarate as a chemopreventive agent in breast cancer. Isr J Med Sci 1995;31:101-5. View abstract.

Kampf D, Roots I, Hildenbrandt AG. Urinary excretion of D-glucarate, an indicator of drug metabolizing enzyme activity, in patients with impaired renal function. Eur J Clin Pharmacol 1980;18:255-61. View abstract.

Mezey E. Increased urinary excretion of D-glucarate acid in alcoholism. Res Commun Chem Pathol Pharmacol 1976;15:735-42. View abstract.

Pantuck EJ, Pantuck CB, Anderson KE, et al. Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 1984;35:161-9. View abstract.

Walaszek Z, Hanausek-Walaszek M, Minton JP, Webb TE. Dietary glucarate as anti-promter of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis. Carcinogenesis 1986;7:1463-6. View abstract.

Walaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake and excretion of D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21:178-90. View abstract.

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