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Cardizem

Last reviewed on RxList: 1/8/2019
Cardizem Side Effects Center

Last reviewed on RxList 1/8/2019

Cardizem (diltiazem hydrochloride) is a calcium channel blocker used to prevent chest pain (angina). Cardizem may help to increase your ability to exercise and decrease how often you may get angina attacks. Cardizem is available in generic form. Common side effects of Cardizem include:

Tell your doctor if you have unlikely but serious side effects of Cardizem including:

  • fainting,
  • slow/irregular/pounding/fast heartbeat,
  • swelling of ankles or feet,
  • shortness of breath,
  • unusual tiredness,
  • unexplained or sudden weight gain,
  • mental/mood changes (such as depression, agitation), or
  • unusual dreams.

Dosage of Cardizem is individually adjusted. Starting with 30 mg four times daily, before meals and at bedtime, dosage is increased gradually (given in divided doses three or four times daily) at 1- to 2-day intervals until optimum response is obtained. The average optimum dosage range is 180 to 360 mg/day. Cardizem may interact with amiodarone, digoxin, atazanavir, cimetidine, quinidine, St. John's wort, azole antifungals, macrolide antibiotics, rifamycins, buspirone, cyclosporine, sirolimus, statins, anti-seizure drugs, benzodiazepines, caffeine, pseudoephedrine, phenylephrine, or other drugs that can raise heart rate. Tell your doctor all medications and supplements you use. Cardizem should be used only when prescribed during pregnancy. This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Our Cardizem (diltiazem hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Salt and sodium are the same. See Answer
Cardizem Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • chest pain;
  • slow heartbeats;
  • pounding heartbeats or fluttering in your chest;
  • a light-headed feeling, like you might pass out; or
  • heart problems--swelling, rapid weight gain, feeling short of breath.

Common side effects may include:

  • swelling;
  • dizziness, weakness;
  • headache;
  • nausea; or
  • rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Cardizem (Diltiazem Hydrochloride)

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Cardizem Professional Information

SIDE EFFECTS

Serious adverse reactions have been rare in studies carried out to date, but it should be recognized that patients with impaired ventricular function and cardiac conduction abnormalities usually have been excluded.

In domestic placebo-controlled angina trials, the incidence of adverse reactions reported during CARDIZEM therapy was not greater than that reported during placebo therapy.

The following represent occurrences observed in clinical studies of angina patients. In many cases, the relationship to CARDIZEM has not been established. The most common occurrences from these studies, as well their frequency of presentation, are edema (2.4%), headache (2.1%), nausea (1.9%), dizziness (1.5%), rash (1.3%), and asthenia (1.2%). In addition, the following events were reported infrequently (less than 1 %):

Cardiovascular

Angina, arrhythmia, AV block (first-degree), AV block (second-or third-degree – see WARNINGS, Cardiac Conduction), bradycardia, bundle branch block, congestive heart failure, ECG abnormality, flushing, hypotension, palpitations, syncope, tachycardia, ventricular extrasystoles.

Nervous System

Abnormal dreams, amnesia, depression, gait abnormality, hallucinations, insomnia, nervousness, paresthesia, personality change, somnolence, tremor.

Gastrointestinal

Anorexia, constipation, diarrhea, dysgeusia, dyspepsia, mild elevations of alkaline phosphatase, SGOT, SGPT, and LDH (see WARNINGS, Acute Hepatic Injury), thirst, vomiting, weight increase.

Dermatological

Petechiae, photosensitivity, pruritus, urticaria.

Other

Amblyopia, CPK elevation, dry mouth, dyspnea, epistaxis, eye irritation, hyperglycemia, hyperuricemia, impotence, muscle cramps, nasal congestion, nocturia, osteoarticular pain, polyuria, sexual difficulties, tinnitus.

The following postmarketing events have been reported infrequently in patients receiving CARDIZEM: acute generalized exanthematous pustulosis, allergic reactions, alopecia, angioedema (including facial or periorbital edema), asystole, erythema multiforme (including Stevens-Johnson syndrome, toxic epidermal necrolysis), extrapyramidal symptoms, gingival hyperplasia, hemolytic anemia, increased bleeding time, leukopenia, photosensitivity (including lichenoid keratosis and hyperpigmentation at sun-exposed skin areas), purpura, retinopathy, myopathy, and thrombocytopenia. There have been observed cases of a generalized rash, some characterized as leukocytoclastic vasculitis. In addition, events such as myocardial infarction have been observed, which are not readily distinguishable from the natural history of the disease in these patients. A definitive cause and effect relationship between these events and CARDIZEM therapy cannot yet be established. Exfoliative dermatitis (proven by rechallenge) has also been reported.

Read the entire FDA prescribing information for Cardizem (Diltiazem Hydrochloride)

Related Resources for Cardizem

Related Health

Read the Cardizem User Reviews »

© Cardizem Patient Information is supplied by Cerner Multum, Inc. and Cardizem Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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Salt and sodium are the same. See Answer

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