Carisoprodol and Aspirin

Last updated on RxList: 5/28/2009
Carisoprodol and Aspirin Side Effects Center

Last reviewed on RxList 5/12/2016

Carisoprodol and Aspirin is a muscle relaxant combined with an analgesic/anti-inflammatory used short-term to treat muscle pain and discomfort. Carisoprodol and Aspirin is usually used along with rest, physical therapy, and other treatments. Carisoprodol helps to relax the muscles and aspirin helps to decrease pain and swelling. Carisoprodol and aspirin is available in generic form. Common side effects of carisoprodol and aspirin include:

The usual adult dosage of carisoprodol and aspirin is 1 or 2 tablets, four times daily. Carisoprodol and aspirin may interact with corticosteroids, mifepristone, anti-platelet drugs, blood thinners, antidepressants, medications that contain pain relievers/fever reducers (aspirin, NSAIDs), other products that cause drowsiness, such as alcohol, antihistamines, drugs for sleep or anxiety, other muscle relaxants, narcotics, and allergy or cough-and-cold products. Tell your doctor all medications and supplements you use. Carisoprodol and aspirin is not recommended for use during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor. Do not use this medication during the last 3 months of pregnancy because of possible harm to the fetus or problems during delivery. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breastfeeding while using this drug is not recommended. Withdrawal symptoms may occur if you suddenly stop taking this medication.

Our Carisoprodol and Aspirin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Carisoprodol and Aspirin Consumer Information
SIDE EFFECTS: Drowsiness, dizziness, headache, stomach upset, nausea/vomiting, or heartburn may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, dark urine, yellowing eyes/skin, persistent nausea/vomiting, hearing problems (such as ringing in the ears, hearing loss), change in amount of urine, fast/pounding heartbeat, unusual tiredness, confusion.

This drug may infrequently cause serious (rarely fatal) bleeding from the stomach or intestines. If you notice any of the following unlikely but serious side effects, stop taking this medication and consult your doctor or pharmacist immediately: black stool, vomit that looks like coffee grounds, persistent stomach/abdominal pain.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Carisoprodol and Aspirin (Carisoprodol and Aspirin)


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Carisoprodol and Aspirin Professional Information


If severe reactions occur, discontinue Carisoprodol and Aspirin Tablets and initiate appropriate symptomatic and supportive therapy. The following side effects which have occurred with the administration of the individual ingredients alone may also occur with the combination.


Central Nervous System: Drowsiness is the most frequent complaint and along with other CNS effects may require dosage reduction. Observed less frequently are dizziness, vertigo and ataxia. Tremor, agitation, irritability, headache, depressive reactions, syncope and insomnia have been infrequent or rare.

Idiosyncratic: Idiosyncratic reactions are very rare. They are usually seen within the period of the first to fourth dose in patients having had no previous contact with the drug (see WARNINGS).

Allergic: Skin rash erythema multiforme, pruritus, eosinophilia and fixed drug eruptions with cross-reaction to meprobamate have been reported. If allergic reactions occur, discontinue Carisoprodol and Aspirin Tablets and treat symptomatically. In evaluating possible allergic reactions, also consider allergy to excipients.

Cardiovascular: Tachycardia, postural hypotension and facial flushing.

Gastrointestinal: Nausea, vomiting, epigastric distress and hiccup.

Hematologic: No serious blood dyscrasias have been attributed to carisoprodol alone.

Leukopenia and pancytopenia have been reported, very rarely, in situations in which other drugs or viral infections may have been responsible.


The most common adverse reactions associated with the use of aspirin have been gastrointestinal, including nausea, vomiting, gastritis, occult bleeding, constipation and diarrhea. Gastric erosion, angioedema, asthma rash, pruritus and urticaria have been reported less commonly. Tinnitus is a sign of high serum salicylate levels (see OVERDOSAGE).

Aspirin Intolerance: Allergic type reactions in aspirin-sensitive individuals may involve the respiratory tract or the skin. Symptoms of the former range from rhinorrhea and shortness of breath to severe asthma, and the latter may consist of urticaria, edema, rash or angioedema (giant hives). These may occur independently or in combination.

Drug Abuse And Dependence

Abuse: In clinical use, abuse has been rare.

Dependence: In clinical use, dependence with Carisoprodol and Aspirin Tablets have been rare and there have been no reports of significant abstinence signs, nevertheless, the following information on the individual ingredients should be kept in mind.

Carisoprodol: In dogs, no withdrawal symptoms occurred after abrupt cessation of carisoprodol from dosages as high as 1 gm/kg/ day. In a study in man, abrupt cessation of 100 mg/kg/day (about five times the recommended daily adult dosage) was followed in some subjects by mild withdrawal symptoms such as abdominal cramps, insomnia, chills, headache and nausea. Delirium and convulsions did not occur (see PRECAUTIONS).

Read the entire FDA prescribing information for Carisoprodol and Aspirin (Carisoprodol and Aspirin)

© Carisoprodol and Aspirin Patient Information is supplied by Cerner Multum, Inc. and Carisoprodol and Aspirin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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