Last reviewed on RxList: 7/12/2021
Carospir Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Carospir?

Carospir (spironolactone) oral suspension is an antagonist of aldosterone indicated for the treatment of NYHA Class III-IV heart failure and reduce d ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure; for use as an add-on therapy for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions; and for the management of edema in adult cirrhotic patients when edema is not responsive to fluid and sodium restrictions.

What Are Side Effects of Carospir?

Common side effects of Carospir include:

Dosage for Carospir

The dose of Carospir depends on the condition being treated.

What Drugs, Substances, or Supplements Interact with Carospir?

Carospir may interact with ACE inhibitors, angiotensin receptor blockers (ARBs), aldosterone blockers, nonsteroidal anti-inflammatory drugs (NSAIDs), heparin and low molecular weight heparin, trimethoprim, lithium, digoxin, cholestyramine, and acetylsalicylic acid. Tell your doctor all medications and supplements you use.

Carospir During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Carospir; it may harm a fetus. Carospir does not pass into breast milk but a metabolite of the drug has been detected in breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Carospir (spironolactone) Oral Suspension Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Heart Disease: Symptoms, Signs, and Causes See Slideshow
Carospir Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • little or no urination;
  • high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; o
  • signs of other electrolyte imbalances--increased thirst or urination, confusion, vomiting, muscle pain, slurred speech, severe weakness, numbness, loss of coordination, feeling unsteady.

Common side effects may include:

  • breast swelling or tenderness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Carospir (Spironolactone)


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer
Carospir Professional Information


The following clinically significant adverse reactions are described elsewhere in the labeling:

The following adverse reactions associated with the use of CAROSPIR were identified in clinical trials or postmarketing reports. Because these reactions were reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency, reliably, or to establish a causal relationship to drug exposure.

Digestive: Gastric bleeding, ulceration, gastritis, diarrhea and cramping, nausea, vomiting.

Reproductive: Gynecomastia [see WARNINGS AND PRECAUTIONS], decreased libido, inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding, breast and nipple pain.

Hematologic: Leukopenia (including agranulocytosis), thrombocytopenia.

Hypersensitivity: Fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis.

Metabolism: Hyperkalemia, electrolyte disturbances [see WARNINGS AND PRECAUTIONS], hyponatremia, hypovolemia.

Musculoskeletal: Leg cramps.

Nervous system /psychiatric: Lethargy, mental confusion, ataxia, dizziness, headache, drowsiness.

Liver / biliary: A very few cases of mixed cholestatic/hepatocellular toxicity, with one reported fatality, have been reported with spironolactone administration.

Renal: Renal dysfunction (including renal failure).

Skin: Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms (DRESS), alopecia, pruritis, chloasma.

Read the entire FDA prescribing information for Carospir (Spironolactone)

© Carospir Patient Information is supplied by Cerner Multum, Inc. and Carospir Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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