Cartia

Last updated on RxList: 9/15/2020
Cartia Side Effects Center

What Is Cartia?

Cartia XT (diltiazem hydrochloride) Extended-Release is a calcium channel blocker used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. Cartia XT is available in generic form.

What Are Side Effects of Cartia?

Common side effects of Cartia XT include:

Dosage for Cartia?

The starting dose of Cartia XT to treat hypertension ranges from 180 to 240 mg once daily. To treat angina, the starting dose range is 120 or 180 mg once daily.

What Drugs, Substances, or Supplements Interact with Cartia?

Cartia XT may interact with amiodarone, buspirone, carbamazepine, cimetidine, cyclosporine, digoxin, lovastatin, rifampin, quinidine, sedatives, antibiotics, antifungal medications, beta-blockers, or HIV/AIDS medicines. Tell your doctor all medications you use.

Cartia During Pregnancy and Breastfeeding

Cartia XT should be used only when prescribed during pregnancy. This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Additional Information

Our Cartia XT (diltiazem hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Salt and sodium are the same. See Answer
Cartia Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • chest pain;
  • slow heartbeats;
  • pounding heartbeats or fluttering in your chest;
  • a light-headed feeling, like you might pass out; or
  • heart problems--swelling, rapid weight gain, feeling short of breath.

Common side effects may include:

  • swelling;
  • dizziness, weakness;
  • headache;
  • nausea; or
  • rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Cartia (Diltiazem Hydrochloride Extended Release Capsules)

SLIDESHOW

How to Lower Blood Pressure: Exercise Tips See Slideshow
Cartia Professional Information

SIDE EFFECTS

Serious adverse reactions have been rare in studies carried out to date, but it should be recognized that patients with impaired ventricular function and cardiac conduction abnormalities have usually been excluded from these studies.

The following table presents the most common adverse reactions reported in placebo-controlled angina and hypertension trials in patients receiving diltiazem hydrochloride extended-release capsule (once-aday dosing) product up to 360 mg with rates in placebo patients shown for comparison.

Diltiazem Hydrochloride Extended-release Capsule (once-a-day) Placebo-controlled Angina and Hypertension Trials Combined

Adverse Reactions Diltiazem Extended-release Capsule (once-a-day)
n=607
Placebo
n=301
Headache 5.4% 5.0%
Dizziness 3.0% 3.0%
Bradycardia 3.3% 1.3%
AV Block First Degree 3.3% 0.0%
Edema 2.6% 1.3%
ECG Abnormality 1.6% 2.3%
Asthenia 1.8% 1.7%

In clinical trials of diltiazem hydrochloride extended-release capsules (Once A Day Dosage), diltiazem hydrochloride tablets and diltiazem hydrochloride extended-release capsules involving over 3200 patients, the most common events (i.e., greater than 1%) were edema (4.6%), headache (4.6%), dizziness (3.5%), asthenia (2.6%), first-degree AV block (2.4%), bradycardia (1.7%), flushing (1.4%), nausea (1.4%), and rash (1.2%).

In addition, the following events were reported infrequently (less than 1%) in angina or hypertension trials:

Cardiovascular: Angina, arrhythmia, AV block (second- or third-degree), bundle branch block, congestive heart failure, ECG abnormalities, hypotension, palpitations, syncope, tachycardia, ventricular extrasystoles.

Nervous System: Abnormal dreams, amnesia, depression, gait abnormality, hallucinations, insomnia, nervousness, paresthesia, personality change, somnolence, tinnitus, tremor.

Gastrointestinal: Anorexia, constipation, diarrhea, dry mouth, dysgeusia, dyspepsia, mild elevations of SGOT, SGPT, LDH, and alkaline phosphatase (see WARNINGS, Acute Hepatic Injury), thirst, vomiting, weight increase.

Dermatological: Petechiae, photosensitivity, pruritus, urticaria.

Other: Amblyopia, CPK increase, dyspnea, epistaxis, eye irritation, hyperglycemia, hyperuricemia, impotence, muscle cramps, nasal congestion, nocturia, osteoarticular pain, polyuria, sexual difficulties.

The following postmarketing events have been reported infrequently in patients receiving diltiazem: acute generalized exanthematous pustulosis, allergic reactions, alopecia, angioedema (including facial or periorbital edema), asystole, erythema multiforme (including Stevens-Johnson syndrome, toxic epidermal necrolysis), exfoliative dermatitis, extrapyramidal symptoms, gingival hyperplasia, hemolytic anemia, increased bleeding time, leukopenia, photosensitivity (including lichenoid keratosis and hyperpigmentation at sun-exposed skin areas), purpura, retinopathy, myopathy, and thrombocytopenia. In addition, events such as myocardial infarction have been observed which are not readily distinguishable from the natural history of the disease in these patients. A number of well-documented cases of generalized rash, some characterized as leukocytoclastic vasculitis, have been reported. However, a definitive cause and effect relationship between these events and diltiazem therapy is yet to be established.

To report SUSPECTED ADVERSE REACTIONS, contact Actavis at 1-800-272-5525 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Read the entire FDA prescribing information for Cartia (Diltiazem Hydrochloride Extended Release Capsules)

© Cartia Patient Information is supplied by Cerner Multum, Inc. and Cartia Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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