Last updated on RxList: 11/4/2020
Cefuroxime Side Effects Center

What Is Cefuroxime?

Cefuroxime and dextrose injection (Brand name: Ceftin) is an antibacterial used to treat lower respiratory tract infections, urinary tract infections, skin infections, septicemia, meningitis, gonorrhea and bone and joint infections. Cefuroxime and dextrose injection is available in generic form.

What Are Side Effects of Cefuroxime?

Common side effects of cefuroxime and dextrose injection include:

Dosage for Cefuroxime

The recommended dosage of cefuroxime and dextrose is 750 mg to 1.5 grams every 8 hours for 5 to 10 days.

What Drugs, Substances, or Supplements Interact with Cefuroxime?

Benedict's solution, Fehling's solution and Clinitest tablets may interact with cefuroxime and dextrose. Tell your doctor all medications you take. Only use cefuroxime and dextrose to treat bacterial infections. It is not an effective treatment for viral infections such as the common cold. Do not skip doses or stop taking cefuroxime and dextrose earlier than directed even if you feel better.

Cefuroxime During Pregnancy and Breastfeeding

Only use cefuroxime and dextrose during pregnancy if clearly needed. Exercise caution if using cefuroxime and dextrose while breastfeeding.

Additional Information

Our Cefuroxime and Dextrose Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Cefuroxime Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • jaundice (yellowing of the skin or eyes);
  • fever, chills, headache, muscle pain;
  • light-headed feeling, like you might pass out;
  • problems with your hearing;
  • a seizure; or
  • kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath.

Common side effects may include:

  • diarrhea;
  • fever and body aches;
  • nausea, vomiting; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Cefuroxime (Cefuroxime Injection)


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Cefuroxime Professional Information


Cefuroxime (cefuroxime (cefuroxime injection) injection) is generally well tolerated. The most common adverse effects have been local reactions following IV administration. Other adverse reactions have been encountered only rarely.

Local Reactions: Thrombophlebitis has occurred with IV administration in 1 in 60 patients.

Gastrointestinal: Gastrointestinal symptoms occurred in 1 in 150 patients and included diarrhea (1 in 220 patients) and nausea (1 in 440 patients). The onset of pseudomembranous colitis may occur during or after antibacterial treatment (see WARNINGS).

Hypersensitivity Reactions: Hypersensitivity reactions have been reported in fewer than 1% of the patients treated with cefuroxime (cefuroxime (cefuroxime injection) injection) and include rash (1 in 125). Pruritus, urticaria, and positive Coombs' test each occurred in fewer than 1 in 250 patients, and, as with other cephalosporins, rare cases of anaphylaxis, drug fever, erythema multiforme, interstitial nephritis, toxic epidermal necrolysis, and Stevens-Johnson syndrome have occurred.

Blood: A decrease in hemoglobin and hematocrit has been observed in 1 in 10 patients and transient eosinophilia in 1 in 14 patients. Less common reactions seen were transient neutropenia (fewer than 1 in 100 patients) and leukopenia (1 in 750 patients). A similar pattern and incidence were seen with other cephalosporins used in controlled studies. As with other cephalosporins, there have been rare reports of thrombocytopenia.

Hepatic: Transient rise in SGOT and SGPT (1 in 25 patients), alkaline phosphatase (1 in 50 patients), LDH (1 in 75 patients), and bilirubin (1 in 500 patients) levels has been noted.

Kidney: Elevations in serum creatinine and/or blood urea nitrogen and a decreased creatinine clearance have been observed, but their relationship to cefuroxime (cefuroxime (cefuroxime injection) injection) is unknown.

Postmarketing Experience with Cefuroxime (cefuroxime (cefuroxime injection) injection) : In addition to the adverse events reported during clinical trials, the following events have been observed during clinical practice in patients treated with cefuroxime (cefuroxime (cefuroxime injection) injection) and were reported spontaneously. Data are generally insufficient to allow an estimate of incidence or to establish causation.

Neurologic: Seizure.
Non-site specific: Angioedema.

Cephalosporin-class Adverse Reactions: In addition to the adverse reactions listed above that have been observed in patients treated with cefuroxime (cefuroxime (cefuroxime injection) injection) , the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:

Adverse Reactions: Vomiting, abdominal pain, colitis, vaginitis including vaginal candidiasis, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, and hemorrhage.

Several cephalosporins, including cefuroxime (cefuroxime (cefuroxime injection) injection) , have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced (see DOSAGE AND ADMINISTRATION). If seizures associated with drug therapy should occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

Altered Laboratory Tests: Prolonged prothrombin time, pancytopenia, agranulocytosis.

Read the entire FDA prescribing information for Cefuroxime (Cefuroxime Injection)

© Cefuroxime Patient Information is supplied by Cerner Multum, Inc. and Cefuroxime Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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