Medical Editor: John P. Cunha, DO, FACOEP
Ceredase (alglucerase) Injection is a manmade form of the enzyme β-glucocerebrosidase used as an enzyme replacement in people with Type I Gaucher disease. Ceredase is not a cure for the condition. The brand name Ceredase is discontinued, but generic versions may be available. Common side effects of Ceredase (alglucerase) Injection include:
- hot flashes
- changes in menstrual periods
- back pain
- swelling in hands or feet
- changes in sense of smell
- upset stomach
- fever or chills, or
- injection site reactions (burning, itching, or swelling
Dosage of Ceredase is individualized for each patient. Ceredase may interact with other drugs. Tell your doctor all medications and supplements you use. Ceredase may be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This drug may pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.
Our Ceredase (alglucerase) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Experience in over 1000 patients treated with Ceredase® (alglucerase injection) has revealed a small number of adverse events. Some of these events were related to the route of administration including discomfort, pruritus, burning and swelling or sterile abscess at the site of venipuncture. The remaining experiences consisted of slight fever, chills, abdominal discomfort, nausea or vomiting. None of these events were judged to require medical intervention.
Symptoms suggestive of hypersensitivity have been noted in a limited number of patients. Onset of such symptoms has occurred during or shortly after infusions; these symptoms have included pruritus, flushing, urticaria/angioedema (a small number of patients have had upper airway involvement), chest discomfort, respiratory symptoms, nausea and abdominal cramping. Hypotension has been reported to occur during a few of these events. (See WARNINGS.)
Pretreatment with antihistamines and reduced rate of infusion has allowed continued use of Ceredase® (alglucerase injection) in most patients. Additional adverse symptoms which have been reported include: fatigue, vasomotor irritability or hot flash, weakness, headache, light headedness, dysosmia, oral ulcerations, backache and transient peripheral edema, and diarrhea. Menstrual abnormalities and false positive pregnancy tests have previously been reported, but due to the introduction of manufacturing steps designed to reduce the level of hCG in Ceredase® (alglucerase injection) , the likelihood of these occurrences is reduced.
Read the entire FDA prescribing information for Ceredase (Alglucerase Injection)