Chemet Side Effects Center

Last updated on RxList: 9/10/2020
Chemet Side Effects Center

What Is Chemet?

Chemet (succimer) is a chelating (binding) agent that binds to lead in the blood and allows it to be passed out in the urine used in the treatment of lead poisoning.

What Are Side Effects of Chemet?

Common side effects of Chemet include:

Dosage for Chemet

The initial dosage of Chemet is 10 mg/kg or 350 mg/m2 every eight hours for five days, then 10 mg/kg or 350 mg/m2 every 12 hours for an additional two weeks. Treatment course lasts 19 days and may be repeated if indicated by blood lead concentration.

What Drugs, Substances, or Supplements Interact with Chemet?

No other medications are known to interact with Chemet. Tell to your doctor all prescription or over-the-counter medications or supplements you use.

Chemet During Pregnancy and Breastfeeding

During pregnancy, Chemet should be used only when prescribed. It is unknown if this medication passes into breast milk. Since this medication is used for lead poisoning and lead may pass into breast milk, do not breast-feed while using this drug.

Additional Information

Our Chemet (succimer) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Chemet Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fever, cold or flu symptoms, cough, trouble breathing;
  • skin sores, rash; or
  • swollen gums, painful mouth sores, pain when swallowing.

Common side effects may include:

  • nausea, vomiting, loss of appetite;
  • diarrhea; or
  • metallic taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Chemet (Succimer)

QUESTION

About how much does an adult human brain weigh? See Answer
Chemet Professional Information

SIDE EFFECTS

Clinical experience with CHEMET has been limited. Consequently, the full spectrum and incidence of adverse reactions including the possibility of hypersensitivity or idiosyncratic reactions have not been determined. The most common events attributable to CHEMET, i.e., gastrointestinal symptoms or increases in serum transaminases, have been observed in about 10% of patients (see PRECAUTIONS). Rashes, some necessitating discontinuation of therapy, have been reported in about 4% of patients. If rash occurs, other causes (e.g. measles) should be considered before ascribing the reaction to CHEMET. Rechallenge with CHEMET may be considered if lead levels are high enough to warrant retreatment. Allergic reactions including urticaria and angioedema have been reported on repeated administration of the drug (see PRECAUTIONS). Mild to moderate neutropenia has been observed in some patients receiving CHEMET (see WARNINGS). Table I presents adverse events reported with the administration of CHEMET for the treatment of lead and other heavy metal intoxication.

TABLE I INCIDENCE OF ADVERSE EVENTS IN DOMESTIC STUDIES REGARDLESS OF ATTRIBUTION OR CHEMET DOSAGE

Pediatric Patients (191)Adults (134)
%(n)%(n)
Digestive:12.02320.928
Nausea, vomiting, diarrhea, appetite loss, hemorrhoidal symptoms, loose stools, metallic taste in mouth.
Body as a Whole:5.21015.721
Back pain, abdominal cramps, stomach pains, head pain, rib pain, chills, flank pain, fever, flu-like symptoms, heavy head/tired, head cold, headache, moniliasis.
Metabolic:4.2810.414
Elevated SGPT, SGOT, alkaline phosphatase, elevated serum cholesterol.
Nervous:1.0212.717
Drowsiness, dizziness, sensorimotor neuropathy, sleepiness, paresthesia.
Skin and Appendages:2.6511.215
Papular rash, herpetic rash, rash, mucocutaneous eruptions, pruritus.
Special Senses:1.023.75
Cloudy film in eye, ears plugged, otitis media, eyes watery.
Respiratory3.770.71
Throat sore, rhinorrhea, nasal congestion, cough.
Urogenital:0.0-3.75
Decreased urination, voiding difficulty, proteinuria increased.
Cardiovascular:0.0-1.82
Arrhythmia
Heme/Lymphatic:0.5*11.5*2
Mild to moderate neutropenia, increased platelet count, intermittent eosinophilia.
Musculoskeletal:0.0-3.04
Kneecap pain, leg pains.
* Does not include neutropenia - see WARNINGS.

To report SUSPECTED ADVERSE REACTIONS, contact Recordati Rare Diseases Inc. at 1-888-575-8344 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Read the entire FDA prescribing information for Chemet (Succimer)

© Chemet Patient Information is supplied by Cerner Multum, Inc. and Chemet Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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