Definition of Chloride

Reviewed on 3/29/2021

Chloride: The major anion (negatively charged substance) in the blood and extracellular fluid (the body fluid that lies outside cells). Blood and other body fluids have almost the same concentration of chloride ion as sea water. The balance of chloride ion (Cl-) is closely regulated by the body.

Significant increases or decreases in chloride can have deleterious and even fatal consequences:

The normal serum range for chloride is 98 - 108 mmol/L.

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