Chlorzoxazone Side Effects Center

Last updated on RxList: 11/9/2020
Chlorzoxazone Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Chlorzoxazone?

Chlorzoxazone (chlorzoxazone tablet) is a centrally acting skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. Chlorzoxazone is available in generic form.

What Are Side Effects of Chlorzoxazone?

Common side effects of chlorzoxazone include:

Dosage for Chlorzoxazone

The usual adult dosage of chlorzoxazone is one 500 mg tablet three or four times daily.

What Drugs, Substances, or Supplements Interact with Chlorzoxazone?

Chlorzoxazone may interact with other drugs. Tell your doctor all medications and supplements you use.

Chlorzoxazone During Pregnancy and Breastfeeding

During pregnancy, chlorzoxazone should be used only if prescribed; it is unknown if it would affect a fetus. Consult your doctor before breastfeeding.

Additional Information

Our Chlorzoxazone (chlorzoxazone tablet) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Chlorzoxazone Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • skin rash, itching, or redness;
  • liver problems--stomach pain (upper right side), loss of appetite, vomiting, fever, unusual tiredness, dark urine, or jaundice (yellowing of the skin or eyes); or
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

  • drowsiness;
  • dizziness; or
  • general ill feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Chlorzoxazone (Chlorzoxazone Tablets)


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Chlorzoxazone Professional Information


Chlorzoxazone containing products are usually well tolerated. It is possible in rare instances that chlorzoxazone may have been associated with gastrointestinal bleeding. Drowsiness, dizziness, lightheadedness, malaise, or
over-stimulation may be noted by an occasional patient. Rarely, allergic-type skin rashes, petechiae, or ecchymoses may develop during treatment. Angioneurotic edema or anaphylactic reactions are extremely rare.
There is no evidence that the drug will cause renal damage. Rarely, a patient may note discoloration of the urine resulting from a phenolic metabolite of chlorzoxazone. This finding is of no known clinical significance.

To report SUSPECTED ADVERSE EVENTS, contact Actavis at 1-800-272-5525 or FDA at 1-800-FDA-1088 or for voluntary reporting of adverse reactions.

Read the entire FDA prescribing information for Chlorzoxazone (Chlorzoxazone Tablets)

© Chlorzoxazone Patient Information is supplied by Cerner Multum, Inc. and Chlorzoxazone Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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