Cleocin Hydrochloride Side Effects Center

Last updated on RxList: 5/19/2020
Cleocin Hydrochloride Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Are Cleocin Hydrochloride Capsules?

Cleocin Hydrochloride Capsules is an antibiotic indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Cleocin Hydrochloride is also indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Cleocin Hydrochloride is available in generic form.

What Are Side Effects of Cleocin Hydrochloride Capsules ?

Common side effects of Cleocin Hydrochloride include:

Dosage for Cleocin Hydrochloride Capsules

The adult dose of Cleocin Hydrochloride to treat serious infections is 150 to 300 mg every 6 hours. The adult dose of Cleocin Hydrochloride to treat more severe infections is 300 to 450 mg every 6 hours.

What Drugs, Substances, or Supplements Interact with Cleocin Hydrochloride Capsules ?

Cleocin Hydrochloride may interact with other neuromuscular blocking agents, inhibitors of CYP3A4 and CYP3A5, and erythromycin. Tell your doctor all medications and supplements you use.

Cleocin Hydrochloride Capsules During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Cleocin Hydrochloride; it is unknown how it may affect a fetus. Cleocin Hydrochloride passes into breast milk and may affect nursing infants. Consult your doctor before breastfeeding.

Additional Information

Our Cleocin Hydrochloride (clindamycin hydrochloride capsules) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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The following reactions have been reported with the use of clindamycin.

Infections and Infestations: Clostridium difficile colitis

Gastrointestinal: Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting, and diarrhea (see BOXED WARNING). The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS). Esophageal ulcer has been reported. An unpleasant or metallic taste has been reported after oral administration.

Hypersensitivity Reactions: Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Severe skin reactions such as Toxic Epidermal Necrolysis, some with fatal outcome, have been reported (See WARNINGS). Cases of Acute Generalized Exanthematous Pustulosis (AGEP), erythema multiforme, some resembling Stevens-Johnson syndrome, anaphylactic shock, anaphylactic reaction and hypersensitivity have also been reported.

Skin and Mucous Membranes: Pruritus, vaginitis, angioedema and rare instances of exfoliative dermatitis have been reported. (See Hypersensitivity Reactions.)

Liver: Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.

Renal: Although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed.

Hematopoietic: Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.

Immune System: Drug reaction with eosinophilia and systemic symptoms (DRESS) cases have been reported.

Musculoskeletal: Cases of polyarthritis have been reported.

Read the entire FDA prescribing information for Cleocin Hydrochloride (Cleocin Hydrochloride Capsules)


Bowel regularity means a bowel movement every day. See Answer

© Cleocin Hydrochloride Patient Information is supplied by Cerner Multum, Inc. and Cleocin Hydrochloride Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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