Medical Editor: John P. Cunha, DO, FACOEP
Cleocin (clindamycin) is an antibiotic used for the treatment of serious infections caused by susceptible anaerobic bacteria. Cleocin is available in generic form. Side effects of Cleocin include:
- abdominal pain,
- pseudomembranous colitis,
- unpleasant or metallic taste in mouth (if Cleocin is injected into a vein),
- pain and swelling at the injection site (if Cleocin is injected into a muscle),
- hypersensitivity reactions (rash and hives),
- vaginal infection, and
- yellowing of skin and eyes (jaundice).
Tell your doctor if you have serious side effects of Cleocin including:
- pain or swelling at injection site (if this drug is injected into a vein),
- dark urine,
- yellowing eyes or skin,
- persistent nausea or vomiting,
- a change in the amount of urine,
- easy bruising or bleeding,
- pain in several joints,
- new signs of infection (e.g., fever, persistent sore throat),
- fast/slow/irregular heartbeat, or
The recommended dose of Cleocin for adults is 150-450 mg orally every 6 hours or intravenous doses of 600-2700 mg daily in 2-4 divided doses. Cleocin may interact with other neuromuscular blocking agents, erythromycin, and hormonal birth control. Tell your doctor all medications and supplements you use. Cleocin has not been adequately evaluated in pregnant women. Cleocin should be used during pregnancy only if it is clearly needed. Cleocin passes into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.
Our Cleocin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Nausea, vomiting, an unpleasant/metallic taste in mouth (if this drug is injected into a vein), or pain at the injection site (if this drug is injected into a muscle) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: pain/swelling at injection site (if this drug is injected into a vein), dark urine, yellowing eyes/skin, persistent nausea/vomiting, change in the amount of urine, easy bruising/bleeding, pain in several joints, new signs of infection (e.g., fever, persistent sore throat), fast/slow/irregular heartbeat, fainting.
Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Cleocin IV (Clindamycin)
The following reactions have been reported with the use of clindamycin.
Infections and Infestations: Clostridium difficile colitis
Gastrointestinal: Antibiotic-associated colitis (see WARNINGS), pseudomembranous colitis, abdominal pain, nausea, and vomiting. The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS). An unpleasant or metallic taste has been reported after intravenous administration of the higher doses of clindamycin phosphate.
Hypersensitivity Reactions: Maculopapular rash and urticaria have been observed during drug therapy. Generalized mild to moderate morbilliform-like skin rashes are the most frequently reported of all adverse reactions.
Severe skin reactions such as Toxic Epidermal Necrolysis, some with fatal outcome, have been reported (see WARNINGS). Cases of Acute Generalized Exanthematous Pustulosis (AGEP), erythema multiforme, some resembling Stevens-Johnson syndrome, have been associated with clindamycin. Anaphylactic shock, anaphylactic reaction and hypersensitivity have also been reported (see WARNINGS).
Liver: Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.
Hematopoietic: Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.
Immune System: Drug reaction with eosinophilia and systemic symptoms (DRESS) cases have been reported.
Local Reactions: Injection site irritation, pain, induration and sterile abscess have been reported after intramuscular injection and thrombophlebitis after intravenous infusion. Reactions can be minimized or avoided by giving deep intramuscular injections and avoiding prolonged use of indwelling intravenous catheters.
Musculoskeletal: Polyarthritis cases have been reported.
Read the entire FDA prescribing information for Cleocin IV (Clindamycin)
© Cleocin IV Patient Information is supplied by Cerner Multum, Inc. and Cleocin IV Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.