Medical Editor: John P. Cunha, DO, FACOEP
Clindacin P (clindamycin phosphate topical solution, 1%) is an antibiotic indicated in the treatment of acne vulgaris. Clindacin P is available in generic form. Common side effects of Clindacin P include:
- skin burning,
- peeling, or
Use a pledget to apply a thin film dose of Clindacin P topical solution to the affected area twice daily. More than one pledget may be used. Each pledget should be used only once and then discarded. Clindacin P may interact with neuromuscular blocking agents. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Clindacin P; it is not expected to harm a fetus when used in the second and third trimesters. It is unknown if Clindacin P would affect a fetus if used in the first trimester. It is unknown if Clindacin P passes into breast milk. Consult your doctor before breastfeeding.
Our Clindacin P (clindamycin phosphate topical solution, 1%) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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In 18 clinical studies of various formulations of topical clindamycin phosphate using placebo vehicle and/or active comparator drugs as controls, patients experienced a number of treatment emergent adverse dermatologic events [see table below].
Number of Patients Reporting Events
|Adverse Event||n=553 (%)||n=148 (%)||n=160 (%)|
|Burning||62 (11)||15 (10)||17 (11)|
|Itching||36 (7)||15 (10)||17 (11)|
|Burning/Itching||60 (11)||# ( – )||# ( – )|
|Dryness||105 (19)||34 (23)||29 (18)|
|Erythema||86 (16)||10 (7)||22 (14)|
|Oiliness/Oily Skin||8 (1)||26 (18)||12* (10)|
|Peeling||61 (11)||# ( – )||11 (7)|
|# not recorded
* of 126 subjects
Orally and parenterally administered clindamycin has been associated with severe colitis which may end fatally. Cases of diarrhea, bloody diarrhea and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with oral and parenteral formulations of clindamycin and rarely with topical clindamycin (see WARNINGS).
Read the entire FDA prescribing information for Clindacin P (Clindacin Topical Solution)