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Clindamycin Phosphate Topical Solution

Last reviewed on RxList: 10/17/2016
Clindamycin Phosphate Topical Solution Side Effects Center

Last reviewed on RxList 10/13/2016

Clindamycin phosphate topical solution is a topical (for the skin) antibiotic used to treat acne vulgaris. Clindamycin phosphate topical solution is available in generic form. Common side effects of clindamycin phosphate topical solution include:

  • skin burning or itching,
  • dry skin,
  • skin redness,
  • oily skin,
  • skin peeling,
  • stomach upset, or
  • abdominal pain.

Apply a thin film of Clindamycin Phosphate Topical Solution or use a Clindamycin Phosphate Topical Solution pledget (pad) twice daily to affected area. More than one pledget may be used if needed. Discard any used pledgets and wash hands thoroughly after application. Clindamycin Phosphate Topical Solution may interact with other neuromuscular blocking agents. There may be other drugs that can interact with Clindamycin Phosphate Topical Solution. Tell your doctor all prescription and over-the-counter medications you are taking. Clindamycin Phosphate Topical Solution should be used during pregnancy only if prescribed. It is not known if the topical form of this medication passes in breast milk. Oral forms of clindamycin pass into breast milk. Consult your doctor before breastfeeding.

Our Clindamycin Phosphate Topical Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Acne is the result of an allergy. See Answer
Clindamycin Phosphate Topical Solution Professional Information


In 18 clinical studies of various formulations of clindamycin phosphate using placebo vehicle and/or active comparator drugs as controls, patients experienced a number of treatment emergent adverse dermatologic events [see table].

Number of Patients Reporting Events

Treatment Emergent Adverse Event Solution
n=553 [%)
Burning 62 (11) 15 (10) 17 (11)
Itching 36 (7) 15 (10) 17 (11)
Burning/Itching 60 (11) # (-) # (-)
Dryness 105(19) 34 (23) 29 (18)
Erythema 86 (16) 10 (7) 22 (14)
Oiliness/OiSy Skin 8 (1) 26 (18) 12* (10)
Peeling 61 (11) # (-) 11 (7)

Orally and parenterally administered clindamycin has been associated with severe colitis which may end fatally.

Cases of diarrhea, bloody diarrhea and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with oral and parenteral formulations of clindamycin and rarely with topical clindamycin (see WARNINGS).

Abdominal pain, gastrointestinal disturbances, gram-negative folliculitis, eye pain and contact dermatitis have also been reported in association with the use of topical formulations of clindamycin.

To report SUSPECTED ADVERSE REACTIONS, contact G&W Laboratories , Inc. at 1-800- 922-1038 or FDA at 1-800-FDA-1088 or

Read the entire FDA prescribing information for Clindamycin Phosphate Topical Solution (Clindamycin Phosphate Topical Solution)


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Related Resources for Clindamycin Phosphate Topical Solution

© Clindamycin Phosphate Topical Solution Patient Information is supplied by Cerner Multum, Inc. and Clindamycin Phosphate Topical Solution Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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