Clindets Side Effects Center

Last updated on RxList: 5/10/2022
Clindets Side Effects Center

What Is Clindets?

Clindets (clindamycin) is a topical solution of an antibiotic used for treating acne.

What Are Side Effects of Clindets?

Side effects of Clindets include:

  • skin burning
  • itching
  • dryness
  • redness
  • oiliness, and
  • peeling

Dosage for Clindets

A thin film dose of Clindets should be applied to affected areas twice daily with an applicator.

What Drugs, Substances, or Supplements Interact with Clindets?

Clindets may interact with other neuromuscular blocking agents. Tell your doctor all medications and supplements you use.

Clindets During Pregnancy or Breastfeeding

During pregnancy, Clindets should only be used if prescribed. It is unknown if Clindets passes into breast milk. Oral and intravenous forms of clindamycin pass into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Clindets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Clindets Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using clindamycin topical and call your doctor at once if you have:

  • severe redness, itching, or dryness of treated skin areas; or
  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose).

Common side effects may include:

  • burning, itching, dryness, peeling or redness of treated skin; or
  • oily skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Clindets Professional Information

SIDE EFFECTS

Clinical Trial Adverse Drug Reactions

The safety was assessed in 150 acne vulgaris patients from a placebo-controlled study in which CLINDETS® or placebo (vehicle) pledgets were applied twice daily over a period of 11 weeks. The number of patients with worsening scores of erythema, peeling and burning is presented in Table 1.

Table 1: Patients with worsening signs or symptoms of acne in a CLINDETS® Clinical Trial

Local Tolerance*
Signs and Symptoms Treatment Number of Patients with Worsening Score
Week 2
n/N (%)
Week 5
n/N (%)
Week 8
n/N (%)
Week 11
n/N(%)
General disorders and
administrative site conditions
Erythema CLINDETS® 1/73 (1.4) 2/72 (2.8) 0 0
Vehicle 1/72 (1.4) 2/70 (2.9) 0 0
Peeling CLINDETS® 2/73 (2.7) 2/72 (2.8) 1/73 (1.4) 0
Vehicle 1/72 (1.4) 3/70 (4.3) 0 0
Burning CLINDETS® 4/73 (5.5) 1/72 (1.4) 2/73 (2.7) 1/73 (1.4)
Vehicle 4/72 (5.6) 4/70 (5.7) 0 0
* Change from Baseline of Signs and Symptoms|

Number of patients reporting common (≥1%) treatment emergent adverse reactions are provided in Table 2.

Table 2: Most common drug related adverse reactions reported by ≥1% of patients in a CLINDETS® Clinical Trial

Adverse Drug Reaction CLINDETS®
% N=75
Vehicle
% N=75
Nervous system
disorders
Paresthesia - 1.3
Headache 1.3 -
Gastrointestinal
disorders
Diarrhea 1.3 1.3
Nausea 1.3 -

Additional Adverse Drug Reactions Reported In Other Clindamycin Phosphate Clinical Trials

The following additional common adverse drug reactions (≥ 1%) have been reported in clinical trials involving other clindamycin phosphate formulations:

Skin and subcutaneous disorders: pruritus, rash, stinging, dryness, oiliness, small red bumps (including gram negative folliculitis pustules).

Immune system disorders: urticaria, whealing, swollen lips.

Gastrointestinal disorders: abdominal cramping.

Post-Market Adverse Drug Reactions

Immune system disorders: allergic reaction.

Gastrointestinal disorders: bloody diarrhea, colitis (including pseudomembranous colitis) (See WARNINGS, Gastrointestinal, CDAD).

Read the entire FDA prescribing information for Clindets (Clindamycin)

© Clindets Patient Information is supplied by Cerner Multum, Inc. and Clindets Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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