Medical Editor: John P. Cunha, DO, FACOEP
What Is Clinimix E?
Clinimix E (amino acids with electrolytes in dextrose with calcium) is indicated as a source of calories, protein, and electrolytes for patients requiring parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated. Clinimix E may be used to treat negative nitrogen balance in patients.
What Are Side Effects of Clinimix E?
Common side effects of Clinimix E include:
- increased urination,
- leakage of fluid from injection site,
- glucose in the urine,
- high blood sugar (hyperglycemia), and
- hyperosmolar coma
Dosage for Clinimix E
The dosage of Clinimix E is individualized based on the patient's clinical condition (ability to adequately metabolize amino acids and dextrose), body weight and nutritional/fluid requirements, as well as additional energy given orally/enterally to the patient.
What Drugs, Substances, or Supplements Interact with Clinimix E?
Clinimix E may interact with drugs or products that can cause high blood potassium (hyperkalemia) or increase the risk of hyperkalemia, such as potassium sparing diuretics (amiloride, spironolactone, triamterene), ACE inhibitors, angiotensin II receptor antagonists, or the immunosuppressants tacrolimus and cyclosporine. Tell your doctor all medications and supplements you use.
Clinimix E During Pregnancy or Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant before using Clinimix E; it is unknown how it would affect a fetus. It is unknown if Clinimix E passes into breast milk. Consult your doctor before breastfeeding.
Our Clinimix E (amino acids with electrolytes in dextrose with calcium) Injection, for Intravenous Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
The following serious adverse reactions are discussed in greater detail in other sections of the prescribing information.
- Pulmonary embolism due to pulmonary vascular precipitates [see WARNINGS AND PRECAUTIONS]
- Death in neonates due to calcium-ceftriaxone precipitates [see WARNINGS AND PRECAUTIONS]
- Hypersensitivity reactions [see WARNINGS AND PRECAUTIONS]
- Risk of Infections [see WARNINGS AND PRECAUTIONS]
- Refeeding syndrome [see WARNINGS AND PRECAUTIONS]
- Hyperglycemia or hyperosmolar hyperglycemic state [see WARNINGS AND PRECAUTIONS]
- Vein damage and thrombosis [see WARNINGS AND PRECAUTIONS]
- Hepatobiliary disorders [see WARNINGS AND PRECAUTIONS]
- Parenteral Nutrition Associated Liver Disease (PNALD) [see WARNINGS AND PRECAUTIONS]
- Electrolyte imbalance and fluid overload [see WARNINGS AND PRECAUTIONS]
The following adverse reactions from voluntary reports or clinical studies have been reported with CLINIMIX E. Because many of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
- Hyperosmolar coma
Drugs That Can Cause Hyperkalemia
Because of its potassium content, CLINIMIX E should be administered with caution in patients treated with agents or products that can cause hyperkalemia or increase the risk of hyperkalemia, such as potassium sparing diuretics (amiloride, spironolactone, triamterene), with ACE inhibitors, angiotensin II receptor antagonists, or the immunosuppressants tacrolimus and cyclosporine.
Read the entire FDA prescribing information for Clinimix E (Amino Acids with Electrolytes in Dextrose with Calcium Injection)
© Clinimix E Patient Information is supplied by Cerner Multum, Inc. and Clinimix E Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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