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Clinoril vs. Celebrex

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Clinoril and Celebrex the Same Thing?

Clinoril (sulindac) and Celebrex (celecoxib) are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain or inflammation caused by arthritis,

Clinoril is also used to treat pain or inflammation caused by ankylosing spondylitis, tendinitis, bursitis, or gout.

Celebrex is also used to treat familial FAP, acute pain, and menstrual cramps.

Side effects of Clinoril and Celebrex that are similar include upset stomach, stomach/abdominal pain, heartburn/indigestion, nausea, gas, bloating, diarrhea, dizziness, headache, nervousness, skin rash, or runny nose.

Side effects of Clinoril that are different from Celebrex include vomiting, constipation, fatigue, itching, dry mouth, increased sweating, blurred vision, or ringing in your ears.

Side effects of Celebrex that are different from Clinoril include stuffy nose, sore throat, and insomnia.

Both Clinoril and Celebrex may interact with alcohol, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), other cold/allergy/pain medicine that contains NSAIDs, diuretics (water pills), lithium, blood thinners, ACE inhibitors, antidepressants, or heart or blood pressure medications.

Clinoril may also interact with cyclosporine, methotrexate, steroids, or oral diabetes medications.

Celebrex may also interact with fluconazole.

What Are Possible Side Effects of Clinoril?

Common side effects of Clinoril include:

  • upset stomach,
  • stomach pain,
  • heartburn,
  • nausea,
  • vomiting,
  • gas,
  • bloating,
  • diarrhea,
  • constipation,
  • dizziness,
  • fatigue,
  • headache,
  • nervousness,
  • skin itching or rash,
  • dry mouth,
  • increased sweating,
  • runny nose,
  • blurred vision, or
  • ringing in your ears.

Tell your doctor if you have unlikely but serious side effects of Clinoril including:

  • swelling of the hands or feet (edema),
  • sudden or unexplained weight gain,
  • mental/mood changes,
  • difficult or painful swallowing, or
  • unusual tiredness.

What Are Possible Side Effects of Celebrex?

Common side effects of Celebrex include:

  • headache,
  • abdominal pain,
  • indigestion,
  • diarrhea,
  • nausea,
  • upset stomach,
  • bloating,
  • gas,
  • dizziness,
  • nervousness,
  • headache,
  • runny or stuffy nose,
  • sore throat,
  • skin rash, and
  • insomnia.

Celebrex may cause serious stomach and intestinal ulcers.

What Is Clinoril?

Clinoril (Sulindac) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout. Clinoril is available in generic form.

What Is Celebrex?

Celebrex used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as different types of arthritis, menstrual cramps, and other types of short-term pain.

What Drugs Interact With Clinoril?

Clinoril may interact with cyclosporine, diuretics (water pills), lithium, methotrexate, blood thinners, steroids, heart or blood pressure medications, oral diabetes medications, ACE inhibitors, celebrex or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications you are taking. Clinoril should be used only when prescribed during the first 6 months of pregnancy. It is not recommended for use during the last 3 months of pregnancy due to possible harm to a fetus and interference with normal labor/delivery. It is unknown if this drug passes into breast milk. Breastfeeding while using this medication is not recommended.

What Drugs Interact With Celebrex?

Do not take Celebrex:

How Should Clinoril Be Taken?

Clinoril is administered under a physician's supervision. The dose of Clinoril varies depending on the disorder being treated and the number of infusions (doses) needed.

How Should Celebrex Be Taken?

Carefully consider the potential benefits and risks of Celebrex and other treatment options before deciding to use Celebrex. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.

Reviewed on 4/11/2019


FDA. Clinoril Product Information.

Pfizer. Celebrex Product Information.


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