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Clinoril vs. Ibuprofen

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Clinoril and Ibuprofen the Same Thing?

Clinoril (sulindac) and ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain or inflammation caused by forms of arthritis.

Clinoril is also used to treat pain or inflammation caused by ankylosing spondylitis, tendinitis, bursitis, or gout.

Ibuprofen is also used for relief of mild to moderate pain, and for treatment of primary menstrual cramps (dysmenorrhea).

Brand names for ibuprofen include Advil, Motrin, Caldolor, and NeoProfen. Ibuprofen is available both over-the-counter (OTC) and by prescription.

Side effects of Clinoril and ibuprofen that are similar include stomach pain, heartburn, nausea, vomiting, gas, bloating, diarrhea, constipation, dizziness, fatigue, headache, nervousness, skin itching or rash, blurred vision, or ringing in your ears.

Side effects of Clinoril that are different from ibuprofen include upset stomach, dry mouth, increased sweating, or runny nose.

Both Clinoril and ibuprofen may interact with alcohol, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), other cold/allergy/pain medicine that contains NSAIDs, diuretics (water pills), lithium, methotrexate, blood thinners, steroids, heart or blood pressure medications, or antidepressants.

Clinoril may also interact with cyclosporine, oral diabetes medications, or ACE inhibitors.

What Are Possible Side Effects of Clinoril?

Common side effects of Clinoril include:

  • upset stomach,
  • stomach pain,
  • heartburn,
  • nausea,
  • vomiting,
  • gas,
  • bloating,
  • diarrhea,
  • constipation,
  • dizziness,
  • fatigue,
  • headache,
  • nervousness,
  • skin itching or rash,
  • dry mouth,
  • increased sweating,
  • runny nose,
  • blurred vision, or
  • ringing in your ears.

Tell your doctor if you have unlikely but serious side effects of Clinoril including:

  • swelling of the hands or feet (edema),
  • sudden or unexplained weight gain,
  • mental/mood changes,
  • difficult or painful swallowing, or
  • unusual tiredness.

What Are Possible Side Effects of Ibuprofen?

Common side effects of Ibuprofen include:

  • stomach pain,
  • constipation,
  • diarrhea,
  • bloating,
  • gas,
  • heartburn,
  • nausea,
  • vomiting,
  • dizziness,
  • headache,
  • nervousness,
  • skin itching or rash,
  • blurred vision, or
  • ringing in the ears.

What Is Clinoril?

Clinoril (Sulindac) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout. Clinoril is available in generic form.

What Is Ibuprofen?

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) indicated for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis, for relief of mild to moderate pain, and for treatment of primary dysmenorrhea. A generic formulation is available.

What Drugs Interact With Clinoril?

Clinoril may interact with cyclosporine, diuretics (water pills), lithium, methotrexate, blood thinners, steroids, heart or blood pressure medications, oral diabetes medications, ACE inhibitors, ibuprofen or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications you are taking. Clinoril should be used only when prescribed during the first 6 months of pregnancy. It is not recommended for use during the last 3 months of pregnancy due to possible harm to a fetus and interference with normal labor/delivery. It is unknown if this drug passes into breast milk. Breastfeeding while using this medication is not recommended.

What Drugs Interact With Ibuprofen?

Ibuprofen may interact with other drugs. Tell your doctor all medications and supplements you use.

How Should Clinoril Be Taken?

Clinoril is administered under a physician's supervision. The dose of Clinoril varies depending on the disorder being treated and the number of infusions (doses) needed.

How Should Ibuprofen Be Taken?

The recommended dose of Ibuprofen should be adjusted to suit individual patients needs but should not exceed 3200 mg in the total daily dose. Use of alcohol and smoking could increase side effects. Safe use of Motrin for use by children has not been established. It is not known whether ibuprofen is harmful to an unborn baby.

Reviewed on 4/11/2019

SOURCE:

FDA. Clinoril Product Information.

https://www.fda.gov/downloads/Drugs/DrugSafety/ucm088573.pdf

FDA. Motrin Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017463s105lbl.pdf

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