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Clinoril vs. Naproxen (Aleve, Anaprox, Naprosyn)

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Clinoril and Naproxen the Same Thing?

Clinoril (sulindac) and naproxen are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout.

Brand names for naproxen include Naprosyn, EC-Naprosyn, and Anaprox/Anaprox DS.

Side effects of Clinoril and naproxen that are similar include upset stomach, stomach or abdominal pain, heartburn, nausea, gas, bloating, diarrhea, constipation, dizziness, headache, nervousness, skin itching or rash, blurred vision, or ringing in your ears.

Side effects of Clinoril that are different from naproxen include vomiting, fatigue, dry mouth, increased sweating, or runny nose.

Both Clinoril and naproxen may interact with alcohol, diuretics (water pills), lithium, methotrexate, blood thinners, steroids, heart or blood pressure medications, antidepressants, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), or other cold/allergy/pain medicine that contains NSAIDs.

Clinoril may also interact with cyclosporine, oral diabetes medications, or ACE inhibitors.

What Are Possible Side Effects of Clinoril?

Common side effects of Clinoril include:

  • upset stomach,
  • stomach pain,
  • heartburn,
  • nausea,
  • vomiting,
  • gas,
  • bloating,
  • diarrhea,
  • constipation,
  • dizziness,
  • fatigue,
  • headache,
  • nervousness,
  • skin itching or rash,
  • dry mouth,
  • increased sweating,
  • runny nose,
  • blurred vision, or
  • ringing in your ears.

Tell your doctor if you have unlikely but serious side effects of Clinoril including:

  • swelling of the hands or feet (edema),
  • sudden or unexplained weight gain,
  • mental/mood changes,
  • difficult or painful swallowing, or
  • unusual tiredness.

What Are Possible Side Effects of Naproxen?

Common side effects of Naproxen include:

  • heartburn,
  • stomach or abdominal pain,
  • upset stomach,
  • nausea,
  • diarrhea,
  • constipation,
  • bloating,
  • gas,
  • dizziness,
  • nervousness,
  • skin rash,
  • headache,
  • blurred vision,
  • ringing in your ears, and
  • itching.

What Is Clinoril?

Clinoril (Sulindac) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout. Clinoril is available in generic form.

What Is Naproxen?

Naproxen is considered a nonsteroidal anti-inflammatory drug (NSAID) and is used for pain management for many diseases, arthritic diseases, and inflammatory diseases such as tendonitis, bursitis, and gout.

What Drugs Interact With Clinoril?

Clinoril may interact with cyclosporine, diuretics (water pills), lithium, methotrexate, blood thinners, steroids, heart or blood pressure medications, oral diabetes medications, ACE inhibitors, naproxen or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications you are taking. Clinoril should be used only when prescribed during the first 6 months of pregnancy. It is not recommended for use during the last 3 months of pregnancy due to possible harm to a fetus and interference with normal labor/delivery. It is unknown if this drug passes into breast milk. Breastfeeding while using this medication is not recommended.

What Drugs Interact With Naproxen?

Naproxen may interact with antidepressants, blood thinners, lithium, methotrexate, diuretics (water pills), steroids, aspirin or other NSAIDs, or heart or blood pressure medications. Tell your doctor all medications and supplements you use. Naprosyn may cause premature closing of the ductus arteriosus in the fetus and does enter breast milk; avoidance of the drug in pregnant and breastfeeding women is suggested.

How Should Clinoril Be Taken?

Clinoril is administered under a physician's supervision. The dose of Clinoril varies depending on the disorder being treated and the number of infusions (doses) needed.

How Should Naproxen Be Taken?

Naproxen is available in several doses and drug configurations; Naproxen tablets with strengths of 250, 375 and 500 mg and as an oral suspension containing 125 mg Naproxen per 5 ml of liquid, EC-Naproxen (delayed release to reduce gastric irritation) with strengths of 375 and 500 mg, Anaprox in 275 mg tablets, Anaprox DS in 550 mg tablets. Almost all Naproxen drugs are recommended to be dosed twice per day (every 12 hours) with children's doses (strength in mg per Kg) based on the child's weight, also twice a day with a maximum dose of 15 mg per Kg per day.

Reviewed on 4/11/2019

SOURCE:

FDA. Clinoril Product Information.

https://www.fda.gov/downloads/Drugs/DrugSafety/ucm088573.pdf

DailyMed. Aleve Product Information.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1266393e-b55e-4e34-9710-0b87209f4158

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