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Clinoril vs. Relafen

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Clinoril and Relafen the Same Thing?

Clinoril (sulindac) and Relafen (nabumetone) are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain or inflammation caused by arthritis.

Clinoril is also used to treat pain or inflammation caused by ankylosing spondylitis, tendinitis, bursitis, or gout.

Side effects of Clinoril and Relafen that are similar include upset stomach, stomach pain, heartburn, gas, bloating, diarrhea, constipation, dizziness, headache, nervousness, skin itching or rash, blurred vision, or ringing in your ears.

Side effects of Clinoril that are different from Relafen include nausea, vomiting, fatigue, dry mouth, increased sweating, or runny nose.

Both Clinoril and Relafen may interact with alcohol, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), other cold/allergy/pain medicine that contains NSAIDs, diuretics (water pills), lithium, methotrexate, blood thinners, steroids, ACE inhibitors, or antidepressants.

Clinoril may also interact with cyclosporine, heart or blood pressure medications, or oral diabetes medications.

What Are Possible Side Effects of Clinoril?

Common side effects of Clinoril include:

  • upset stomach,
  • stomach pain,
  • heartburn,
  • nausea,
  • vomiting,
  • gas,
  • bloating,
  • diarrhea,
  • constipation,
  • dizziness,
  • fatigue,
  • headache,
  • nervousness,
  • skin itching or rash,
  • dry mouth,
  • increased sweating,
  • runny nose,
  • blurred vision, or
  • ringing in your ears.

Tell your doctor if you have unlikely but serious side effects of Clinoril including:

  • swelling of the hands or feet (edema),
  • sudden or unexplained weight gain,
  • mental/mood changes,
  • difficult or painful swallowing, or
  • unusual tiredness.

What Are Possible Side Effects of Relafen?

Common side effects of Relafen include:

  • upset stomach,
  • heartburn,
  • stomach pain,
  • diarrhea,
  • constipation,
  • bloating,
  • gas,
  • dizziness,
  • headache,
  • nervousness,
  • skin itching or rash,
  • blurred vision, or
  • ringing in your ears.

Nonsteroidal anti-inflammatory drugs (including Relafen) may rarely increase the risk for a heart attack or stroke. Bleeding from the gastrointestinal tract is another potentially serious side effect of Relafen.

What Is Clinoril?

Clinoril (Sulindac) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout. Clinoril is available in generic form.

What Is Relafen?

Relafen (nabumetone) is a nonsteroidal anti-inflammatory (NSAID) drug used to treat inflammation and pain caused by arthritis. The brand name drug Relafen is no longer available in the U.S. Generic versions may be available.

What Drugs Interact With Clinoril?

Clinoril may interact with cyclosporine, diuretics (water pills), lithium, methotrexate, blood thinners, steroids, heart or blood pressure medications, oral diabetes medications, ACE inhibitors, relafen or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications you are taking. Clinoril should be used only when prescribed during the first 6 months of pregnancy. It is not recommended for use during the last 3 months of pregnancy due to possible harm to a fetus and interference with normal labor/delivery. It is unknown if this drug passes into breast milk. Breastfeeding while using this medication is not recommended.

What Drugs Interact With Relafen?

Relafen may interact with antidepressants, blood thinners, lithium, methotrexate, diuretics (water pills), steroids, aspirin or other NSAIDs, or ACE inhibitors.. There are no adequate, well-controlled studies in pregnant women, and Relafen should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Use during late pregnancy should be avoided because of the known effects of NSAIDs in the fetal cardiovascular system (closure of ductus arteriosus). It is not known whether Relafen is excreted in human milk; a decision should be made whether to discontinue breastfeeding or to discontinue the Relafen.

How Should Clinoril Be Taken?

Clinoril is administered under a physician's supervision. The dose of Clinoril varies depending on the disorder being treated and the number of infusions (doses) needed.

How Should Relafen Be Taken?

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

Reviewed on 4/11/2019

SOURCE:

FDA. Clinoril Product Information.

https://www.fda.gov/downloads/Drugs/DrugSafety/ucm088573.pdf

FDA. Relafen Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/019583s023lbl.pdf

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