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Clinoril vs. Zipsor, Zorvolex

Reviewed on 10/2/2019

Are Clinoril and Zipsor, Zorvolex the Same Thing?

Clinoril (sulindac) and Zorvolex, Zipsor, and Flector (diclofenac) are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain.

Clinoril is used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout.

Zorvolex, Zipsor, and Flector are used to treat mild to moderate acute pain in adults.

Side effects of Clinoril and Zorvolex, Zipsor, and Flector that are similar include stomach/abdominal pain, heartburn/indigestion, nausea, vomiting, gas, diarrhea, constipation, dizziness, headache, skin itching, increased sweating, and runny or stuffy nose.

Side effects of Clinoril that are different from Zorvolex, Zipsor, and Flector include upset stomach, bloating, fatigue, nervousness, rash, dry mouth, blurred vision, and ringing in your ears.

Side effects of Zorvolex, Zipsor, and Flector that are different from Clinoril include swelling (edema), drowsiness, pain in extremities, sinus infection, high or low blood pressure, upper respiratory tract infection, urinary tract infection (UTI), arthritis, cough, and back pain. Flector is a topical patch and side effects may also include dryness, itching, peeling, scaling, burning, redness, and other skin irritation where the patch is applied.

Both Clinoril and Zorvolex, Zipsor, and Flector may interact with alcohol, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), cyclosporine, diuretics (water pills), lithium, methotrexate, blood thinners, heart or blood pressure medications, ACE inhibitors, antidepressants, and other cold/allergy/pain medicine that contains NSAIDs.

Clinoril may also interact with steroids and oral diabetes medications.

Zorvolex, Zipsor, and Flector may also interact with pemetrexed, voriconazole, and rifampin.

What Are Possible Side Effects of Clinoril?

Common side effects of Clinoril include:

  • upset stomach,
  • stomach pain,
  • heartburn,
  • nausea,
  • vomiting,
  • gas,
  • bloating,
  • diarrhea,
  • constipation,
  • dizziness,
  • fatigue,
  • headache,
  • nervousness,
  • skin itching or rash,
  • dry mouth,
  • increased sweating,
  • runny nose,
  • blurred vision, or
  • ringing in your ears.

Tell your doctor if you have unlikely but serious side effects of Clinoril including:

  • swelling of the hands or feet (edema),
  • sudden or unexplained weight gain,
  • mental/mood changes,
  • difficult or painful swallowing, or
  • unusual tiredness.

What Are Possible Side Effects of Zipsor, Zorvolex?

Common side effects of Zipsor, Zorvolex include:

  • abdominal pain,
  • constipation,
  • diarrhea,
  • indigestion,
  • nausea,
  • vomiting,
  • dizziness,
  • headache,
  • drowsiness,
  • itching, and
  • increased sweating

What Is Clinoril?

Clinoril (Sulindac) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain or inflammation caused by arthritis, ankylosing spondylitis, tendinitis, bursitis, or gout. Clinoril is available in generic form.

What Is Zipsor, Zorvolex?

Zipsor, Zorvolex (diclofenac potassium) Liquid Filled Capsules is a nonsteroidal anti-inflammatory drug (NSAID) indicated for relief of mild to moderate acute pain.


Ankylosing spondylitis is a type of __________ that affects the __________. See Answer

What Drugs Interact With Clinoril?

Clinoril may interact with cyclosporine, diuretics (water pills), lithium, methotrexate, blood thinners, steroids, heart or blood pressure medications, oral diabetes medications, ACE inhibitors, zipsor or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications you are taking. Clinoril should be used only when prescribed during the first 6 months of pregnancy. It is not recommended for use during the last 3 months of pregnancy due to possible harm to a fetus and interference with normal labor/delivery. It is unknown if this drug passes into breast milk. Breastfeeding while using this medication is not recommended.

What Drugs Interact With Zipsor, Zorvolex?

Zipsor, Zorvolex Gel may interact with aspirin and anticoagulants.

Tell your doctor all medications and supplements you use. Zipsor is not recommended for use during pregnancy; it may harm a fetus. Starting at 30 weeks gestation, Zipsor should be avoided. It is unknown if Zipsor passes into breast milk. Consult your doctor before breastfeeding.

How Should Clinoril Be Taken?

Clinoril is administered under a physician's supervision. The dose of Clinoril varies depending on the disorder being treated and the number of infusions (doses) needed.

How Should Zipsor, Zorvolex Be Taken?

The dosage of Zipsor, Zorvolex is 25 mg four times a day.


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FDA. Clinoril Product Information.

Assertio Pharmaceuticals. Zipsor Product Information.

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