Clobex Lotion Side Effects Center

Last updated on RxList: 10/25/2021
Clobex Lotion Side Effects Center

What Is Clobex Lotion?

Clobex (clobetasol propionate) Lotion is a topical (for the skin) steroid used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. Clobex Lotion is available in generic form.

What Are Side Effects of Clobex Lotion?

Common side effects of Clobex Lotion include:

  • mild skin rash,
  • itching,
  • burning, or
  • redness,
  • dry or cracking skin,
  • thinning or softening of the skin,
  • skin rash or irritation around the mouth,
  • swollen hair follicles,
  • spider veins,
  • changes in color of treated skin,
  • blisters,
  • pimples,
  • crusting of treated skin, or
  • stretch marks.

Tell your doctor if you have severe irritation of any treated skin, or if you show signs of absorbing Clobex Lotion topical through your skin, such as:

  • blurred vision, or
  • seeing halos around lights,
  • mood changes,
  • sleep problems (insomnia),
  • weight gain,
  • puffiness in your face,
  • muscle weakness, or
  • feeling tired.

Dosage for Clobex Lotion

The recommended dose is to apply Clobex Lotion 0.05% to the affected skin areas twice daily and rub in gently and completely. It is not likely other drugs you take orally or inject will have an effect on topically applied Clobex.

What Drugs, Substances, or Supplements Interact with Clobex Lotion?

But many drugs can interact with each other. Tell your doctor all medications and supplements you use.

Clobex Lotion During Pregnancy or Breastfeeding

During pregnancy, Clobex should be used only if prescribed. It may be harmful to a fetus. It is unknown if this medication passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Clobex (clobetasol propionate) Lotion Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Types of Psoriasis: Medical Pictures and Treatments See Slideshow
Clobex Lotion Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain in your face and shoulders, slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects may include:

  • burning, itching, swelling, or irritation of treated skin;
  • dry or cracking skin;
  • redness or crusting around your hair follicles;
  • spider veins;
  • stretch marks, thinning skin;
  • rash or hives;
  • acne; or
  • temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Clobex Lotion (Clobetasol Propionate Lotion)


Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer
Clobex Lotion Professional Information


In controlled clinical trials with CLOBEX® (clobetasol propionate) Lotion, 0.05%, the following adverse reactions have been reported: burning/stinging, skin dryness, irritation, erythema, folliculitis, pruritus, skin atrophy, and telangiectasia.

The pooled incidence of local adverse reactions in trials for psoriasis and atopic dermatitis with CLOBEX® (clobetasol propionate) Lotion, 0.05% at 1.0% or greater was:

Adverse Reaction Incidence
Skin Atrophy 4.20%
Telangiectasia 3.20%
Discomfort Skin 1.30%
Skin Dry 1.00%

Other local adverse events occurred at rates less than 1.0%. Similar rates of local adverse reactions were reported in the comparator (clobetasol propionate cream, 0.05%). Most local adverse events were rated as mild to moderate and they are not affected by age, race or gender.

The following additional local adverse reactions have been reported with topical corticosteroids. They may occur more frequently with the use of occlusive dressings and higher potency corticosteroids, including clobetasol propionate. These reactions are listed in an approximate decreasing order of occurrence: irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, striae and miliaria.

Read the entire FDA prescribing information for Clobex Lotion (Clobetasol Propionate Lotion)

© Clobex Lotion Patient Information is supplied by Cerner Multum, Inc. and Clobex Lotion Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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