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Clomid

Last reviewed on RxList: 10/17/2016
Clomid Patient Information Including Side Effects

Brand Names: Clomid, Serophene

Generic Name: clomiphene (Pronunciation: KLOE mih feen)

What is clomiphene (Clomid, Serophene)?

Clomiphene stimulates the release of hormones necessary for ovulation to occur.

Clomiphene is used to stimulate ovulation (the release of an egg) when a woman's ovaries can produce a follicle but hormonal stimulation is deficient.

Clomiphene may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of clomiphene (Clomid, Serophene)?

Stop taking clomiphene and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

The ovarian hyperstimulation syndrome (OHSS) has been reported to occur in patients receiving clomiphene. Symptoms of OHSS include swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, and nausea or vomiting. OHSS can be fatal. Notify your doctor immediately or seek emergency medical attention if you develop any of these side effects.

Other side effects may also occur. Notify your doctor if you experience

  • ovarian enlargement presenting as abdominal or pelvic pain, tenderness, pressure, or swelling;
  • flushing;
  • nausea, vomiting, or diarrhea;
  • breast tenderness or discomfort;
  • blurred vision or other visual disturbances;
  • headache; or
  • abnormal uterine bleeding.

Clomiphene may increase the likelihood of multiple births. Multiple births may carry additional risk both for the mother and for the fetuses.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about clomiphene (Clomid, Serophene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Clomiphene may cause blurred vision or other visual side effects during or shortly after therapy. Notify your doctor immediately if you develop any visual side effects and use caution when performing hazardous activities, especially under conditions of variable lighting.

Clomiphene may increase the likelihood of multiple births. Multiple births may carry additional risk both for the mother and for the fetuses.

Clomid Patient Information including How Should I Take

Who should not take clomiphene (Clomid, Serophene)?

Do not take clomiphene without first talking to your doctor if you

  • might be pregnant;
  • have a thyroid problem or another endocrine disorder;
  • have undiagnosed vaginal bleeding;
  • have endometriosis or endometrial carcinoma;
  • have uterine fibroids;
  • have liver disease;
  • have ovarian cysts or ovarian enlargement not due to polycystic ovarian syndrome; or
  • have any other serious or chronic medical illness.

You may not be able to take clomiphene, or you may require a lower dose or special monitoring if you have any of the conditions listed above.

Do not take clomiphene if you are pregnant. Clomiphene is in the FDA pregnancy category X. This means that it is known to cause birth defects.

It is not known whether clomiphene pass into breast milk. Do not take clomiphene without first talking to your doctor if you are breast-feeding a baby.

How should I take clomiphene (Clomid, Serophene)?

Use clomiphene exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.

Take each dose with a full glass of water.

Clomiphene is usually taken in 5 day cycles. Follow your doctor's instructions.

Store clomiphene at room temperature, away from direct light, moisture, and heat.

Clomid Patient Information including If I Miss a Dose

What happens if I miss a dose (Clomid, Serophene)?

Contact your doctor if you miss a dose of clomiphene.

What happens if I overdose (Clomid, Serophene)?

Seek emergency medical attention.

Symptoms of a clomiphene overdose include nausea, vomiting, flushing, blurred vision, visual spots or flashes, and abdominal pain.

What should I avoid while taking clomiphene (Clomid, Serophene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Clomiphene may cause blurred vision or other visual side effects during or shortly after therapy. Notify your doctor immediately if you develop any visual side effects and use caution when performing hazardous activities, especially under conditions of variable lighting.

What other drugs will affect clomiphene (Clomid, Serophene)?

There are no known interactions between clomiphene and other medicines. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about clomiphene written for health professionals that you may read.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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