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Codeine Sulfate

Last reviewed on RxList: 9/21/2018
Codeine Sulfate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 9/21/2018

Codeine sulfate is an opioid analgesic (pain reliever) drug used to treat mild to moderate pain. Codeine sulfate is available in generic form. Common side effects of codeine sulfate include:

  • drowsiness,
  • lightheadedness,
  • dizziness,
  • sedation,
  • shortness of breath,
  • nausea,
  • vomiting,
  • stomach pain,
  • sweating,
  • constipation,
  • dry mouth,
  • flushing,
  • itching, or
  • rash.

The usual adult dosage for codeine sulfate tablets is 15 mg to 60 mg repeated up to every four hours as needed for pain. The maximum 24-hour dose is 360 mg. As with any opioid drug product, the dosing regimen is adjusted for each patient. Codeine sulfate may interact with alcohol, other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, other medicines that can make you sleepy or slow your breathing, pentazocine, nalbuphine, butorphanol, or buprenorphine. Tell your doctor all medications and supplements you use. There are no adequate and well-controlled studies in pregnant women. Codeine should be used during pregnancy only if the potential benefit justifies the potential risk. Codeine sulfate can pass into breast milk and may harm a nursing baby. The use of codeine sulfate by some nursing mothers may lead to life-threatening side effects in the baby. Consult your doctor before breastfeeding.

Our Codeine sulfate Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Codeine Sulfate Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

  • noisy breathing, sighing, shallow breathing, breathing that stops during sleep;
  • a slow heart rate or weak pulse;
  • a light-headed feeling, like you might pass out;
  • confusion, unusual thoughts or behavior;
  • feelings of extreme happiness or sadness;
  • seizure (convulsions);
  • problems with urination; or
  • low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects include:

  • feeling dizzy or drowsy;
  • constipation; or
  • nausea, vomiting, stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Codeine Sulfate (Codeine)

QUESTION

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Codeine Sulfate Professional Information

SIDE EFFECTS

Serious adverse reactions associated with codeine are respiratory depression and, to a lesser degree, circulatory depression, respiratory arrest, shock, and cardiac arrest.

The most frequently observed adverse reactions with codeine administration include drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, sweating, and constipation.

Other adverse reactions include allergic reactions, euphoria, dysphoria, abdominal pain, and pruritis.

Other less frequently observed adverse reactions expected from opioid analgesics, including codeine sulfate, include:

Cardiovascular system: faintness, flushing, hypotension, palpitations, syncope

Digestive System: abdominal cramps, anorexia, diarrhea, dry mouth, gastrointestinal distress, pancreatitis

Nervous system: anxiety, drowsiness, fatigue, headache, insomnia, nervousness, shakiness, somnolence, vertigo, visual disturbances, weakness

Skin and Appendages: rash, sweating, urticaria

Read the entire FDA prescribing information for Codeine Sulfate (Codeine)

Related Resources for Codeine Sulfate

Read the Codeine Sulfate User Reviews »

© Codeine Sulfate Patient Information is supplied by Cerner Multum, Inc. and Codeine Sulfate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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