Last updated on RxList: 5/14/2020
Cogentin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Cogentin?

Cogentin (benztropine mesylate) is an anti-Parkinson's agent and anticholinergic agent prescribed for treating the symptoms of Parkinson's disease and related drug-induced side effects. Cogentin is available as a generic drug.

What Are Side Effects of Cogentin?

Common side effects of Cogentin include:

  • drowsiness,
  • dizziness,
  • headache,
  • loss of appetite,
  • nausea,
  • stomach upset,
  • vision changes,
  • sleeplessness,
  • trembling of the hands,
  • numbness in your fingers,
  • depression,
  • memory problems,
  • nervousness,
  • excitability,
  • dry mouth,
  • double vision, or
  • increased sensitivity to light.

Dosage for Cogentin

Cogentin usual adult dose ranges from 0.5 - 6 mg/day in 1-2 divided doses.

What Drugs, Substances, or Supplements Interact with Cogentin?

Cogentin may interact with alcohol, other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), amantadine, glycopyrrolate, mepenzolate, diuretics (water pills), potassium supplements, antidepressants, atropine, belladonna, dimenhydrinate, meclizine, methscopolamine, scopolamine, bladder or urinary medications, bronchodilators, irritable bowel medications, medicines to treat Alzheimer's dementia, or medicines to treat psychiatric disorders. Tell your doctor all medications and supplements you use.

Cogentin During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant while using Cogentin; it is unknown if it will harm a fetus. It is unknown if Cogentin passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Cogentin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. articles.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Dementia, Alzheimer's Disease, and Aging Brains See Slideshow
Cogentin Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • dry mouth that causes trouble talking or swallowing;
  • little or no urination;
  • uncontrolled muscle movements;
  • vomiting, severe constipation;
  • fast heartbeats;
  • muscle weakness;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • confusion, hallucinations; or
  • severe skin rash.

Common side effects may include:

  • dry mouth;
  • blurred vision;
  • constipation; or
  • nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Cogentin (Benztropine Mesylate Injection)


Parkinson's disease is only seen in people of advanced age. See Answer
Cogentin Professional Information


The adverse reactions below, most of which are anticholinergic in nature, have been reported and within each category are listed in order of decreasing severity.

Cardiovascular: Tachycardia.

Digestive: Paralytic ileus, constipation, vomiting, nausea, dry mouth.

If dry mouth is so severe that there is difficulty in swallowing or speaking, or loss of appetite and weight, reduce dosage, or discontinue the drug temporarily.

Slight reduction in dosage may control nausea and still give sufficient relief of symptoms. Vomiting may be controlled by temporary discontinuation, followed by resumption at a lower dosage.

Nervous System

Toxic psychosis, including confusion, disorientation, memory impairment, visual hallucinations; exacerbation of pre-existing psychotic symptoms; nervousness; depression; listlessness; numbness of fingers.

Special Senses

Blurred vision, dilated pupils.


Urinary retention, dysuria.

Metabolic/Immune or Skin

Occasionally, an allergic reaction, e.g., skin rash, develops. If this cannot be controlled by dosage reduction, the medication should be discontinued.


Heat stroke, hyperthermia, fever.

To report SUSPECTED ADVERSE REACTIONS, contact Lundbeck Inc. at 1-800455-1141 or FDA at 1-800-FDA-1088 or

Read the entire FDA prescribing information for Cogentin (Benztropine Mesylate Injection)

© Cogentin Patient Information is supplied by Cerner Multum, Inc. and Cogentin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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