Last updated on RxList: 10/6/2020
Colestid Side Effects Center

What Is Colestid?

Colestid (micronized colestipol hydrochloride) Tablets is a cholesterol-lowering drug used to lower "bad" cholesterol in the blood, which is also called LDL (low-density lipoprotein) cholesterol. Lowering LDL cholesterol may reduce the risk of hardened arteries, which can lead to heart attacks, stroke, and circulation problems. Colestid is available in generic form.

What Are Side Effects of Colestid?

Common side effects of Colestid include:

Tell your doctor if you experience rare but serious side effects of Colestid including:

  • difficulty swallowing
  • chest pain or pressure
  • severe stomach/abdominal pain
  • severe constipation
  • bloody/black/tarry stools
  • unusual bleeding or bruising
  • rapid breathing
  • confusion
  • muscle or joint pain, or
  • loss of appetite

Dosage for Colestid?

For adults, Colestid Tablets are recommended in doses of 2 to 16 grams/day given once or in divided doses. The starting dose should be 2 grams once or twice daily. Dosage increases of 2 grams, once or twice daily should occur at 1- or 2-month intervals.

What Drugs, Substances, or Supplements Interact with Colestid?

Colestid may interact with steroids, heart medications, diuretics (water pills), antibiotics, or other cholesterol-lowering medications. Tell your doctor all medications you are taking.

Colestid During Pregnancy and Breastfeeding

During pregnancy, Colestid should be used only when prescribed. It may affect the absorption of certain nutrients. This medication is unlikely to pass into breast milk. It may affect the absorption of certain nutrients. Consult your doctor before breastfeeding.

Our Colestid (micronized colestipol hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What is cholesterol? See Answer
Colestid Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • trouble swallowing;
  • severe constipation or stomach pain; or
  • black, bloody, or tarry stools.

Common side effects may include:

  • constipation; or
  • hemorrhoids.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Colestid (Colestipol)


How to Lower Your Cholesterol & Save Your Heart See Slideshow
Colestid Professional Information



The most common adverse reactions are confined to the gastrointestinal tract. To achieve minimal GI disturbance with an optimal LDL-C lowering effect, a gradual increase of dosage starting with 2 grams, once or twice daily is recommended. Constipation is the major single complaint and at times is severe. Most instances of constipation are mild, transient, and controlled with standard treatment. Increased fluid intake and inclusion of additional dietary fiber should be the first step; a stool softener may be added if needed. Some patients require decreased dosage or discontinuation of therapy. Hemorrhoids may be aggravated.

Other, less frequent gastrointestinal complaints consist of abdominal discomfort (abdominal pain and cramping), intestinal gas (bloating and flatulence), indigestion and heartburn, diarrhea and loose stools, and nausea and vomiting. Bleeding hemorrhoids and blood in the stool have been infrequently reported. Peptic ulceration, cholecystitis, and cholelithiasis have been rarely reported in patients receiving colestipol hydrochloride granules, and are not necessarily drug related.

Difficulty swallowing and transient esophageal obstruction have been rarely reported in patients taking COLESTID Tablets.

Transient and modest elevations of aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT) and alkaline phosphatase were observed on one or more occasions in various patients treated with colestipol hydrochloride.

The following nongastrointestinal adverse reactions have been reported with generally equal frequency in patients receiving COLESTID Tablets, colestipol granules, or placebo in clinical studies:


Chest pain, angina, and tachycardia have been infrequently reported.


Rash has been infrequently reported. Urticaria and dermatitis have been rarely noted in patients receiving colestipol hydrochloride granules.


Musculoskeletal pain, aches and pains in the extremities, joint pain and arthritis, and backache have been reported.


Headache, migraine headache, and sinus headache have been reported. Other infrequently reported complaints include dizziness, light-headedness, and insomnia.


Anorexia, fatigue, weakness, shortness of breath, and swelling of the hands or feet, have been infrequently reported.

Read the entire FDA prescribing information for Colestid (Colestipol)

© Colestid Patient Information is supplied by Cerner Multum, Inc. and Colestid Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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