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Last reviewed on RxList: 12/12/2016
CoLyte Side Effects Center

Last reviewed on RxList 02/08/2017

Colyte (peg-3350 & electrolytes) for Oral Solution is a colon lavage preparation indicated for bowel cleansing prior to colonoscopy or barium enema X-ray examination. Side effects of Colyte include:

  • stomach pain or cramps,
  • gas,
  • bloating,
  • feelings of fullness in the stomach/abdomen,
  • no bowel movement within two hours after use,
  • rectal pain or irritation,
  • nausea, or
  • gagging.

Tell your doctor if you have serious side effects of Colyte including:

  • vomit that is bloody or looks like coffee grounds,
  • chest pain,
  • fainting,
  • fast or irregular heartbeat,
  • sudden shortness of breath,
  • severe or persistent stomach or abdominal pain,
  • bloody stools,
  • rectal bleeding, or
  • seizures.

Colyte with flavor packs can be administered orally or by nasogastric tube. Patients should fast at least three hours prior to administration. A one hour waiting period after the appearance of clear liquid stool should be allowed prior to examination to complete bowel evacuation. No foods except clear liquids should be permitted prior to examination after Colyte with flavor packs. Ask your doctor or pharmacist if you should take current medications before or after drinking Colyte oral solution. Avoid taking other medications, vitamins, or mineral supplements within 1 hour before drinking Colyte solution. Any medications you take just before a bowel cleansing will not be properly absorbed into your body. Colyte may be harmful to a developing fetus, and it is not known whether the solution passes into breast milk or could harm a nursing baby. Colyte should be given to pregnant and breastfeeding patients only if clearly needed. Safety and effectiveness in pediatric patients have not been established.

Our Colyte (peg-3350 & electrolytes) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

CoLyte Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe stomach pain or bloating;
  • no bowel movement within 2 hours after use; or
  • gagging, choking, or vomiting.

If you have any of these side effects, you may need to drink the medication more slowly, or stop using it for a short time.

Less serious side effects may include:

  • mild stomach cramps, gas, or bloating;
  • rectal pain or irritation;
  • nausea; or
  • passing gas.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for CoLyte (PEG Electrolytes Solution)

CoLyte Professional Information


Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in clinical studies of another drug and may not reflect the rates observed in practice.

Nausea, abdominal fullness and bloating are the most common adverse reactions (occurring in up to 50% of patients) to administration of Colyte. Abdominal cramps, vomiting and anal irritation occur less frequently. These adverse reactions are transient and usually subside rapidly. Isolated cases of urticaria, rhinorrhea, dermatitis, and rarely anaphylaxis, angioedema, tongue edema, and face edema have been reported which may represent allergic reactions.

To report suspected adverse events contact Meda Pharmaceuticals Inc. at toll free 1-888-317-0001 or FDA at 1-800-FDA-1088 or

Read the entire FDA prescribing information for CoLyte (PEG Electrolytes Solution)

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© CoLyte Patient Information is supplied by Cerner Multum, Inc. and CoLyte Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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