Last updated on RxList: 5/26/2021
CoLyte Side Effects Center

What Is CoLyte?

Colyte (peg-3350 & electrolytes) for Oral Solution is a colon lavage preparation indicated for bowel cleansing prior to colonoscopy or barium enema X-ray examination.

What Are Side Effects of CoLyte?

Side effects of Colyte include:

  • stomach pain or cramps,
  • gas,
  • bloating,
  • feelings of fullness in the stomach/abdomen,
  • no bowel movement within two hours after use,
  • rectal pain or irritation,
  • nausea, or
  • gagging.

Tell your doctor if you have serious side effects of Colyte including:

  • vomit that is bloody or looks like coffee grounds,
  • chest pain,
  • fainting,
  • fast or irregular heartbeat,
  • sudden shortness of breath,
  • severe or persistent stomach or abdominal pain,
  • bloody stools,
  • rectal bleeding, or
  • seizures.

Dosage for CoLyte

Colyte with flavor packs can be administered orally or by nasogastric tube. Patients should fast at least three hours prior to administration. A one hour waiting period after the appearance of clear liquid stool should be allowed prior to examination to complete bowel evacuation. No foods except clear liquids should be permitted prior to examination after Colyte with flavor packs. Ask your doctor or pharmacist if you should take current medications before or after drinking Colyte oral solution.

What Drugs, Substances, or Supplements Interact with CoLyte?

Avoid taking other medications, vitamins, or mineral supplements within 1 hour before drinking Colyte solution. Any medications you take just before a bowel cleansing will not be properly absorbed into your body.

CoLyte During Pregnancy and Breastfeeding

Colyte may be harmful to a developing fetus, and it is not known whether the solution passes into breast milk or could harm a nursing baby. Colyte should be given to pregnant and breastfeeding patients only if clearly needed. Safety and effectiveness in pediatric patients have not been established.

Additional Information

Our Colyte (peg-3350 & electrolytes) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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CoLyte Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • no bowel movement within 2 hours after use;
  • vomiting;
  • dizziness, feeling like you might pass out;
  • little or no urination;
  • a seizure; or
  • signs of an electrolyte imbalance--increased thirst or urination, dry mouth, confusion, constipation, muscle pain or weakness, leg cramps, irregular heartbeats, tingly feeling.

You may need to drink the liquid more slowly, or stop using it for a short time if you have certain side effects. Call your doctor for instructions if you have:

  • gagging, choking, severe stomach pain or bloating;
  • nausea, vomiting, headache, trouble drinking liquids, little or no urinating; or
  • fever, sudden or severe stomach pain, severe diarrhea, rectal bleeding or bright red bowel movements.

Common side effects may include:

  • vomiting, stomach pain, indigestion, bloating;
  • rectal pain or irritation;
  • hunger, thirst, mild nausea;
  • trouble sleeping; or
  • dizziness, chills.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for CoLyte (PEG Electrolytes Solution)


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CoLyte Professional Information


Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in clinical studies of another drug and may not reflect the rates observed in practice.

Nausea, abdominal fullness and bloating are the most common adverse reactions (occurring in up to 50% of patients) to administration of Colyte. Abdominal cramps, vomiting and anal irritation occur less frequently. These adverse reactions are transient and usually subside rapidly. Isolated cases of urticaria, rhinorrhea, dermatitis, and rarely anaphylaxis, angioedema, tongue edema, and face edema have been reported which may represent allergic reactions.

To report suspected adverse events contact Meda Pharmaceuticals Inc. at toll free 1-866-210-5953 or FDA at 1-800-FDA-1088 or


Drugs That May Increase Risks Due To Fluid and Electrolyte Abnormalities

Use caution when prescribing Colyte for patients with conditions, or who are using medications, that increase the risk for fluid and electrolyte disturbances or may increase the risk of adverse events of seizures, arrhythmias, and prolonged QT in the setting of fluid and electrolyte abnormalities. Consider additional patient evaluations as appropriate (see PRECAUTIONS) in patients taking these concomitant medications.

Potential For Altered Drug Absorption

Oral medication administered within one hour of the start of administration of Colyte may be flushed from the gastrointestinal tract and the medication may not be absorbed properly.

Read the entire FDA prescribing information for CoLyte (PEG Electrolytes Solution)

© CoLyte Patient Information is supplied by Cerner Multum, Inc. and CoLyte Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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