Combipatch vs. Climara Pro

Are Combipatch and Climara Pro the Same Thing?

CombiPatch (estradiol, norethindrone acetate) and Climara Pro (estradiol/levonorgestrel) are transdermal patches that are combinations of female hormones used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating ("hot flashes" or "hot flushes").

CombiPatch is also used to treat vulvar and vaginal changes (itching, burning, dryness in or around the vagina, difficulty or burning with urination) caused by menopause, and to replace estrogen in conditions such as hypogonadism, removal of the ovaries, or primary ovarian failure that result in a lack of estrogen.

Climara is also used to prevent osteoporosis (bone loss) in menopausal women.

What Are Possible Side Effects of Combipatch?

Common side effects of Combipatch include:

  • skin redness/irritation/rash at the application site,
  • abdominal pain,
  • nausea,
  • vomiting,
  • bloating,
  • breast tenderness or enlargement,
  • weakness,
  • swelling of the hands or feet,
  • spotty darkening of the skin (particularly on the face),
  • difficulty wearing contact lenses,
  • vaginal irritation or discomfort,
  • changes in menstrual cycle,
  • painful menstruation,
  • breakthrough bleeding,
  • headache, or
  • weight changes.

What Are Possible Side Effects of Climara Pro?

Common side effects of Climara Pro include:

  • patch application site reactions (skin redness, irritation, or skin rash),
  • abdominal pain,
  • nausea,
  • vomiting,
  • bloating,
  • breast tenderness or swelling,
  • headache,
  • weight changes,
  • swelling of the hands or feet,
  • darkened spots on the skin of your face,
  • contact lens discomfort,
  • vaginal irritation or discomfort,
  • depression, or
  • changes in your menstrual periods.

What is Combipatch?

CombiPatch (estradiol, norethindrone acetate transdermal system) is a combination of female hormones used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating ("hot flashes" or "hot flushes"); to treat vulvar and vaginal changes (itching, burning, dryness in or around the vagina, difficulty or burning with urination) caused by menopause; and to replace estrogen in conditions such as hypogonadism, removal of the ovaries, or primary ovarian failure that result in a lack of estrogen.

What is Climara Pro?

Climara Pro (estradiol/levonorgestrel) transdermal patch is a combination of female hormones used to treat menopause symptoms such as hot flashes, and to prevent osteoporosis (bone loss) in menopausal women. Climara Pro will not prevent dementia, heart attack, heart disease, or stroke.

QUESTION

If menopause occurs in a woman younger than ___ years, it is considered to be premature. See Answer

What Drugs Interact With Combipatch?

CombiPatch may interact with anticoagulants (blood thinners).

What Drugs Interact With Climara Pro?

CombiPatch and Climara may interact with anticoagulants (blood thinners).

How Should Combipatch Be Taken?

Two CombiPatch transdermal delivery systems are available: 0.05 mg estradiol with 0.14 mg NETA per day (9 sq cm) and 0.05 mg estradiol with 0.25 mg NETA per day (16 sq cm). The lowest effective dose should be used.

How Should Climara Pro Be Taken?

A Climara Pro patch with a dose of 0.045 mg estradiol / 0.015 mg levonorgestrel (22 sq cm) is worn continuously on the lower abdomen. A new system should be applied weekly during a 28-day cycle.

SLIDESHOW

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References

RxList. Combipatch Product Monograph.
https://www.rxlist.com/ibuprofen-drug.htm
RxList. Climara Pro Side Effects Drug Center.
https://www.rxlist.com/climara-pro-side-effects-drug-center.htm

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