Compazine vs. Phenergan

Are Compazine and Phenergan the Same Thing?

Compazine (prochlorperazine) and Phenergan (promethazine HCI) are used to control nausea and vomiting.

Compazine is also used to treat psychotic disorders such as schizophrenia and to treat anxiety.

Phenergan is also used to treat allergic symptoms such as rash, itching, and runny nose.

The brand names Compazine and Phenergan are discontinued in the U.S. Generic versions may be available.

Compazine and Phenergan belong to different drug classes. Compazine is a phenothiazine anti-psychotic and Phenergan is an antihistamine.

Side effects of Compazine and Phenergan that are similar include dizziness, drowsiness, anxiety, dry mouth, stuffy nose, blurred vision, constipation, swelling in hands or feet, weight gain, impotence, or trouble having an orgasm.

Side effects of Compazine that are different from Phenergan include sleep problems (insomnia), strange dreams, breast swelling or discharge, missed menstrual periods, mild itching, skin rash, headache, and low blood pressure (hypotension).

Side effects of Phenergan that are different from Compazine include ringing in your ears.

Both Compazine and Phenergan may interact with atropine, lithium, blood pressure medications, blood thinners, asthma medications, bladder or urinary medications, ulcer or irritable bowel medications, medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor.

Compazine may also interact with diuretics (water pills), antibiotics, birth control pills or hormone replacement estrogens, drugs to treat prostate disorders, insulin or oral diabetes medications, medication for nausea, vomiting, or motion sickness, medications to treat or prevent malaria, medications used for general anesthesia, medicines used to prevent organ transplant rejection, numbing medicine, stimulants, ADHD medication, Many other medicines can interact with Compazine.

Phenergan may also interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, seizure medications, antidepressants, anxiety medicines, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, or MAO inhibitors.

What Are Possible Side Effects of Compazine?

Side effects of Compazine include:

  • dizziness,
  • drowsiness,
  • anxiety,
  • sleep problems (insomnia),
  • strange dreams,
  • dry mouth,
  • stuffy nose,
  • blurred vision,
  • constipation,
  • breast swelling or discharge,
  • missed menstrual periods,
  • weight gain,
  • swelling in hands or feet,
  • impotence,
  • trouble having an orgasm,
  • mild itching,
  • skin rash,
  • headache, and
  • low blood pressure (hypotension).

What Are Possible Side Effects of Phenergan?

Common side effects of Phenergan include:

  • drowsiness,
  • dizziness,
  • anxiety,
  • blurred vision,
  • dry mouth,
  • stuffy nose,
  • ringing in your ears,
  • weight gain,
  • swelling in your hands or feet,
  • impotence,
  • trouble having an orgasm, or
  • constipation.

What Is Compazine?

Compazine (prochlorperazine) is a phenothiazine anti-psychotic used to treat psychotic disorders such as schizophrenia. Compazine (prochlorperazine) is also used to treat anxiety, and to control severe nausea and vomiting.

What Is Phenergan?

Phenergan (promethazine HCI) is an antihistamine used to treat nausea and vomiting related to certain conditions (e.g., motion sickness, before/after surgery). Phenergan is also used to treat allergic symptoms such as rash, itching, and runny nose. The brand name Phenergan is discontinued in the U.S. Phenergan is available as a generic drug.

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What Drugs Interact With Compazine?

Compazine may interact with antibiotics, anti-malaria medications, or other medicines to prevent or treat nausea and vomiting. Compazine may also interact with atropine, lithium, diuretics (water pills), birth control pills or hormone replacement estrogens, blood pressure medications, blood thinners, asthma medications, drugs to treat prostate disorders, incontinence medications, insulin or oral diabetes medications, medications used for general anesthesia, medicines used to prevent organ transplant rejection, numbing medicine, stimulants, ADHD medication, ulcer or irritable bowel medications, or medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor.

Do not stop using Compazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms such as nausea, vomiting, dizziness, or feeling shaky.

What Drugs Interact With Phenergan?

Phenergan may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, seizure medications, antidepressants, anxiety medicines, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary medications, MAO inhibitors, medicines to treat Parkinson's disease, restless leg syndrome medications, medicines to treat pituitary gland tumor, or medicines to treat stomach ulcer or irritable bowel syndrome. Tell your doctor all medications and supplements you use. Phenergan Tablets and Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Phenergan is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Phenergan Tablets and Suppositories, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

How Should Compazine Be Taken?

Dosage of Compazine i adjusted to the response of the individual. Begin with the lowest recommended dosage.

How Should Phenergan Be Taken?

The dose of Phenergan to treat allergies is 25 mg taken before retiring. The adult dose of Phenergan to treat motion sickness is 25 mg taken twice daily. The dose of Phenergan for the active therapy of nausea and vomiting in children or adults is 25 mg.

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References
SOURCES:

DailyMed. Compazine Product Monograph.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bdba30b-53b4-427a-af74-7a39b52130b2

DailyMed. Phenergan Product Information.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6f7e47cc-f823-4336-8107-f980e3049617

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