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Compazine vs. Reglan

Are Compazine and Reglan the Same Thing?

Compazine (prochlorperazine) and Reglan (metoclopramide) are used to control severe nausea and vomiting.

Compazine is also used to treat psychotic disorders such as schizophrenia and to treat anxiety.

Reglan is also used to treat loss of appetite, heartburn, and early satiety (feeling of fullness).

Compazine and Reglan belong to different drug classes. Compazine is a phenothiazine anti-psychotic and Reglan is a dopamine antagonist.

The brand name Compazine is discontinued in the U.S. Generic versions may be available.

Side effects of Compazine and Reglan that are similar include dizziness, drowsiness, sleep problems (insomnia), breast tenderness/swelling or discharge, changes in your menstrual periods, and headache.

Side effects of Compazine that are different from Reglan include anxiety, strange dreams, dry mouth, stuffy nose, blurred vision, constipation, weight gain, swelling in hands or feet, impotence, trouble having an orgasm, mild itching, skin rash, and low blood pressure (hypotension).

Side effects of Reglan that are different from Compazine include decreased energy, tiredness, diarrhea, nausea, vomiting, restlessness, feeling unwell (malaise), or urinating more than usual.

Both Compazine and Reglan may interact with atropine, blood pressure medications, asthma medications, bladder or urinary medications, insulin, medication for nausea/vomiting/motion sickness, medicines to prevent organ transplant rejection, irritable bowel medications, ulcer medications, or medicines to treat Parkinson's disease.

Compazine may also interact with lithium, diuretics (water pills), antibiotics, birth control pills or hormone replacement estrogens, blood thinners, drugs to treat prostate disorders, oral diabetes medications, medications to treat or prevent malaria, medications used for general anesthesia, numbing medicine, stimulants, ADHD medication, restless leg syndrome medicines, or pituitary gland tumor. Many other medicines can interact with Compazine.

Reglan may also interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), acetaminophen, digoxin, tetracycline, MAO inhibitors, or medicines to treat psychiatric disorders.

What Are Possible Side Effects of Compazine?

Side effects of Compazine include:

  • dizziness,
  • drowsiness,
  • anxiety,
  • sleep problems (insomnia),
  • strange dreams,
  • dry mouth,
  • stuffy nose,
  • blurred vision,
  • constipation,
  • breast swelling or discharge,
  • missed menstrual periods,
  • weight gain,
  • swelling in hands or feet,
  • impotence,
  • trouble having an orgasm,
  • mild itching,
  • skin rash,
  • headache, and
  • low blood pressure (hypotension).

What Are Possible Side Effects of Reglan?

Common side effects of Reglan include:

  • decreased energy,
  • tiredness,
  • diarrhea,
  • dizziness,
  • drowsiness,
  • headache,
  • nausea,
  • vomiting,
  • restlessness,
  • malaise,
  • trouble sleeping (insomnia),
  • breast tenderness or swelling,
  • changes in your menstrual periods, or
  • urinating more than usual.

Tell your doctor if you experience serious side effects of Reglan including:

What Is Compazine?

Compazine (prochlorperazine) is a phenothiazine anti-psychotic used to treat psychotic disorders such as schizophrenia. Compazine (prochlorperazine) is also used to treat anxiety, and to control severe nausea and vomiting.

What Is Reglan?

Reglan (metoclopramide) is a dopamine antagonist that is used as an antiemetic (anti-vomiting) agent used to treat nausea, vomiting, loss of appetite, heartburn and early satiety (feeling of fullness). Reglan is available in generic form.

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What Drugs Interact With Compazine?

Compazine may interact with antibiotics, anti-malaria medications, or other medicines to prevent or treat nausea and vomiting. Compazine may also interact with atropine, lithium, diuretics (water pills), birth control pills or hormone replacement estrogens, blood pressure medications, blood thinners, asthma medications, drugs to treat prostate disorders, incontinence medications, insulin or oral diabetes medications, medications used for general anesthesia, medicines used to prevent organ transplant rejection, numbing medicine, stimulants, ADHD medication, ulcer or irritable bowel medications, or medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor.

Do not stop using Compazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms such as nausea, vomiting, dizziness, or feeling shaky.

What Drugs Interact With Reglan?

Reglan may also interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), acetaminophen, cyclosporine, digoxin, glycopyrrolate, insulin, levodopa, mepenzolate, tetracycline, atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bladder or urinary medications, blood pressure medications, bronchodilators, irritable bowel medications, or MAO inhibitors.

How Should Compazine Be Taken?

Dosage of Compazine i adjusted to the response of the individual. Begin with the lowest recommended dosage.

How Should Reglan Be Taken?

The dose of Reglan to treat allergies is 25 mg taken before retiring. The adult dose of Reglan to treat motion sickness is 25 mg taken twice daily. The dose of Reglan for the active therapy of nausea and vomiting in children or adults is 25 mg.

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References
SOURCES:

DailyMed. Compazine Product Monograph.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bdba30b-53b4-427a-af74-7a39b52130b2

DailyMed. Reglan Product Monograph.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de55c133-eb08-4a35-91a2-5dc093027397

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