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Compazine vs. Thorazine

Are Compazine and Thorazine the Same Thing?

Compazine (prochlorperazine) and Thorazine (chlorpromazine) are phenothiazine anti-psychotics used to treat psychotic disorders such as schizophrenia. Compazine and Thorazine are also used to treat anxiety, and to control nausea and vomiting.

Thorazine is also used to treat manic-depression, severe behavioral problems in children, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.

The brand names Compazine and Thorazine are discontinued in the U.S. Generic versions may be available.

Side effects of Compazine and Thorazine that are similar include dizziness, drowsiness, anxiety, sleep problems (insomnia), dry mouth, stuffy nose, blurred vision, constipation, breast swelling or discharge, changes in menstrual periods, weight gain, swelling in hands or feet, impotence, trouble having an orgasm.

Side effects of Compazine that are different from Thorazine include strange dreams, mild itching, skin rash, headache, and low blood pressure (hypotension).

Both Compazine and Thorazine may interact with atropine, lithium, antibiotics, birth control pills or hormone replacement estrogens, blood pressure medications, blood thinners, asthma medications or bronchodilators, incontinence medications, insulin or oral diabetes medications, drugs to treat prostate disorders, medication for nausea/vomiting/motion sickness, medications to treat or prevent malaria, medications used for general anesthesia, medicines used to prevent organ transplant rejection, numbing medicine, stimulants, ADHD medication, ulcer or irritable bowel medications, medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor.

Compazine may also interact with diuretics (water pills) and many other medicines.

Thorazine may also interact with phenytoin and many other medicines.

What Are Possible Side Effects of Compazine?

Side effects of Compazine include:

  • dizziness,
  • drowsiness,
  • anxiety,
  • sleep problems (insomnia),
  • strange dreams,
  • dry mouth,
  • stuffy nose,
  • blurred vision,
  • constipation,
  • breast swelling or discharge,
  • missed menstrual periods,
  • weight gain,
  • swelling in hands or feet,
  • impotence,
  • trouble having an orgasm,
  • mild itching,
  • skin rash,
  • headache, and
  • low blood pressure (hypotension).

What Are Possible Side Effects of Thorazine?

Common side effects of Thorazine include:

  • dizziness,
  • drowsiness,
  • anxiety,
  • sleep problems (insomnia),
  • breast swelling or discharge,
  • changes in menstrual periods,
  • weight gain,
  • swelling in hands or feet,
  • dry mouth,
  • stuffy nose,
  • blurred vision,
  • constipation,
  • impotence, or
  • trouble having an orgasm.

What Is Compazine?

Compazine (prochlorperazine) is a phenothiazine anti-psychotic used to treat psychotic disorders such as schizophrenia. Compazine (prochlorperazine) is also used to treat anxiety, and to control severe nausea and vomiting.

What Is Thorazine?

Thorazine (chlorpromazine) is a phenothiazine anti-psychotic medication used to treat psychotic disorders such as schizophrenia or manic-depression, and severe behavioral problems in children. Thorazine is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.

QUESTION

Pancreatitis is inflammation of an organ in the abdomen called the pancreas. See Answer

What Drugs Interact With Compazine?

Compazine may interact with antibiotics, anti-malaria medications, or other medicines to prevent or treat nausea and vomiting. Compazine may also interact with atropine, lithium, diuretics (water pills), birth control pills or hormone replacement estrogens, blood pressure medications, blood thinners, asthma medications, drugs to treat prostate disorders, incontinence medications, insulin or oral diabetes medications, medications used for general anesthesia, medicines used to prevent organ transplant rejection, numbing medicine, stimulants, ADHD medication, ulcer or irritable bowel medications, or medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor.

Do not stop using Compazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms such as nausea, vomiting, dizziness, or feeling shaky.

What Drugs Interact With Thorazine?

Thorazine may interact with atropine, lithium, phenytoin, antibiotics, birth control pills or hormone replacement estrogens, blood pressure medications, blood thinners, asthma medications or bronchodilators, incontinence medications, insulin or oral diabetes medications, medication for nausea, vomiting, or motion sickness, medications to treat or prevent malaria, medications used for general anesthesia, medicines used to prevent organ transplant rejection, numbing medicine, stimulants, ADHD medication, ulcer or irritable bowel medication, medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor. Many other medicines can interact with chlorpromazine. Tell your doctor all medications you use. During pregnancy, chlorpromazine should be used only if prescribed. It may cause side effects in a newborn if the mother takes the medication during pregnancy. Chlorpromazine can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you are on a high dosage of this medication and abruptly stop taking it.

How Should Compazine Be Taken?

Dosage of Compazine i adjusted to the response of the individual. Begin with the lowest recommended dosage.

How Should Thorazine Be Taken?

Dosing of chlorpromazine depends on severity of the condition, and the patient's response to the drug.

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Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

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Reviewed on 4/23/2019
References
SOURCES:

DailyMed. Compazine Product Monograph.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bdba30b-53b4-427a-af74-7a39b52130b2

DailyMed. Thorazine Product Monograph.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=33c01749-ef88-4e9c-8b45-0f026af1d5fd
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