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Compro

Last reviewed on RxList: 4/10/2017
Compro Patient Information Including Side Effects

Brand Names: Compazine, Compro

Generic Name: prochlorperazine (rectal)

What is rectal prochlorperazine (Compazine, Compro)?

Prochlorperazine is a phenothiazine (FEEN-oh-THYE-a-zeen). It works by changing the actions of chemicals in your brain.

Prochlorperazine is used to treat psychotic disorders such as schizophrenia. It is also used to treat anxiety, and to control severe nausea and vomiting.

Prochlorperazine may also be used for purposes not listed in this medication guide.

What are the possible side effects of rectal prochlorperazine (Compazine, Compro)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

High doses or long-term use of prochlorperazine can cause a serious movement disorder that may not be reversible. The longer you use prochlorperazine, the more likely you are to develop this disorder, especially if you are a diabetic or an older adult.

Stop using prochlorperazine and call your doctor if you have any of these signs of a serious movement disorder:

  • tremors or shaking in your arms or legs;
  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); or
  • any new or unusual muscle movements you cannot control.

Also call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • agitation;
  • jaundice (yellowing of the skin or eyes);
  • slow heart rate, weak pulse, fainting, slow breathing;
  • fever, chills, sore throat, mouth sores;
  • new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight; or
  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Side effects may be more likely in older adults.

Common side effects may include:

  • dizziness, drowsiness;
  • feeling restless or jittery;
  • blurred vision;
  • constipation;
  • breast swelling or discharge, a missed menstrual period;
  • sleep problems (insomnia); or
  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about rectal prochlorperazine (Compazine, Compro)?

You should not use prochlorperazine if you have recently used alcohol, sedatives, tranquilizers, or opioid medication.

Prochlorperazine may increase the risk of death in older adults with dementia-related conditions and is not approved for this use.

Do not give this medicine to a child younger than 2 years old or weighing less than 20 pounds.

Compro Patient Information including How Should I Take

What should I discuss with my healthcare provider before using rectal prochlorperazine (Compazine, Compro)?

You should not use prochlorperazine if you are allergic to it, or if you have recently used alcohol, sedatives, tranquilizers, or opioid medication.

Do not give this medicine to a child younger than 2 years old or weighing less than 20 pounds. Talk with your doctor before giving this medicine to a child of any age who has been ill with a fever or flu symptoms.

Prochlorperazine may increase the risk of death in older adults with dementia-related conditions and is not approved for this use.

Tell your doctor if you have ever had:

Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are using prochlorperazine.

Prochlorperazine may harm an unborn baby. Tell your doctor if you are pregnant.

Using antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop using prochlorperazine without your doctor's advice.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

How should I use rectal prochlorperazine (Compazine, Compro)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not take a rectal suppository by mouth. It is for use only in your rectum.

Try to empty your bowel and bladder just before using the prochlorperazine suppository.

Wash your hands before and after inserting the suppository.

Remove the wrapper, but avoid handling the suppository too long or it will melt.

Lie on your back with your knees up toward your chest. Gently insert the suppository into your rectum about 1 inch, pointed tip first.

Stay lying down for a few minutes while the suppository melts. You should feel little or no discomfort. Avoid using the bathroom for at least an hour.

If you need surgery or a medical procedure, tell the doctor you currently use this medicine. You may need to stop for a short time.

Do not stop using prochlorperazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture and heat.

Compro Patient Information including If I Miss a Dose

What happens if I miss a dose (Compazine, Compro)?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose (Compazine, Compro)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause dry mouth, constipation, bloating or stomach cramps, extreme drowsiness or feeling restless and agitated, changes in heart rate, fever, and fainting.

What should I avoid while using rectal prochlorperazine (Compazine, Compro)?

Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol with this medicine can cause side effects.

What other drugs will affect rectal prochlorperazine (Compazine, Compro)?

Using prochlorperazine with other drugs that slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Many drugs can affect prochlorperazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Compazine, Compro)?

Your pharmacist can provide more information about rectal prochlorperazine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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