Acetaminophen Chlorpheniramine Phenylephrine

Reviewed on 9/22/2021

QUESTION

Which illness is known as a viral upper respiratory tract infection? See Answer

What Is Acetaminophen/Chlorpheniramine/Phenylephrine Used For and How Does it Work?

Acetaminophen/chlorpheniramine/phenylephrine is an over-the-counter (OTC) product used for relief of cold and flu symptoms.

Acetaminophen/chlorpheniramine/phenylephrine is available under the following different brand names: Tylenol Allergy Multi-Symptom, Dristan Cold, Children's Tylenol Plus Cold, Tylenol Sinus Congestion & Pain Nighttime, and Robitussin Peak Cold Nighttime Nasal Relief.

Dosages of Acetaminophen/Chlorpheniramine/Phenylephrine

Dosage Forms and Strengths

Tablet

  • 325mg/2mg/5mg

Dosage Considerations – Should be Given as Follows:

Relief of Cold and Flu Symptoms

Adults and Children over 12 years:

  • Dristan Cold: 2 tablets orally every 4 hours; not to exceed 12 tablets/day
  • Tylenol Allergy Multi-Symptom: 2 tablets orally every 4 hours; not to exceed 12 tablets/day
  • Tylenol Sinus Congestion & Pain Nighttime: 2 tablets orally every 4 hours; not to exceed 12 tablets/day
  • Robitussin Peak Cold Nighttime Nasal Relief: 2 tablets every 4 hours as needed; not to exceed 12 tablets/day

Children under 12 years: Ask a pediatrician

What Are Side Effects Associated with Using Acetaminophen/Chlorpheniramine/Phenylephrine?

Common side effects of Acetaminophen/Chlorpheniramine/Phenylephrine include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Acetaminophen/Chlorpheniramine/Phenylephrine?

  • Severe interactions of acetaminophen_chlorpheniramine_phenylephrine include:
  • Acetaminophen/chlorpheniramine/phenylephrine has serious interactions with at least 28 different drugs.
  • Acetaminophen/chlorpheniramine/phenylephrine has moderate interactions with at least 281 different drugs.
  • Acetaminophen/chlorpheniramine/phenylephrine has mild interactions with at least 64 different drugs.

What Are Warnings and Precautions for Acetaminophen/Chlorpheniramine/Phenylephrine?

Warnings

This medication contains acetaminophen/chlorpheniramine/phenylephrine. Do not take Tylenol Allergy Multi-Symptom, Dristan Cold, Children's Tylenol Plus Cold, Tylenol Sinus Congestion & Pain Nighttime, or Robitussin Peak Cold Nighttime Nasal Relief if you are allergic to acetaminophen/chlorpheniramine/phenylephrine or any ingredients contained in this drug.

Contraindications

  • Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency
  • Chlorpheniramine may cause significant confusional symptoms; not for administration to under 2 years of age
  • Use of monoamine oxidase inhibitor (MAOI) within 14 days
  • Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many over-the-counter (OTC) products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose

Effects of Drug Abuse

  • No information available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Acetaminophen/Chlorpheniramine/Phenylephrine?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Acetaminophen/Chlorpheniramine/Phenylephrine?"

Cautions

Pregnancy and Lactation

There is no information available regarding use of acetaminophen/chlorpheniramine/phenylephrine during pregnancy or while breastfeeding.

Pregnant or breastfeeding patients should seek advice of a health professional before using over-the-counter (OTC) drugs.

SLIDESHOW

A Cold or The Flu? How to Tell the Difference See Slideshow
References
Source: https://reference.medscape.com/drug/tylenol-allergy-multi-symptom-dristan-cold-acetaminophen-chlorpheniramine-phenylephrine-iv-999370

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