Acetaminophen Dextromethorphan Phenylephrine

Reviewed on 9/21/2021

Brand Name and Other Names: Alka-Seltzer Plus Day Cold, Theraflu Daytime Severe Cold & Cough, Tylenol Cold Multi-Symptom Daytime, Tylenol Cold Head Congestion Daytime, Vicks DayQuil Cold/Flu, Alka-Seltzer Plus Day Severe Cold, Cough & Flu, Alka-Seltzer Plus Day Sinus Congestion, Allergy & Cough, Alka-Seltzer Plus Severe Sinus Congestion & Cough

Generic Name: Acetaminophen/Dextromethorphan/Phenylephrine

Drug Class: Cough/Cold, Non-narcotic Combos; Analgesic Expectorant Combos

QUESTION

Which illness is known as a viral upper respiratory tract infection? See Answer

What Is Acetaminophen/Dextromethorphan/Phenylephrine Used For and How Does it Work?

Acetaminophen/dextromethorphan/phenylephrine is an over-the-counter (OTC) product used for symptomatic relief of cough and congestion.

Acetaminophen/dextromethorphan/phenylephrine is available under the following different brand names: Alka-Seltzer Plus Day Cold, Theraflu Daytime Severe Cold & Cough, Tylenol Cold Multi-Symptom Daytime, Tylenol Cold Head Congestion Daytime, Vicks DayQuil Cold/Flu, Alka-Seltzer Plus Day Severe Cold, Cough & Flu, Alka-Seltzer Plus Day Sinus Congestion, Allergy & Cough, and Alka-Seltzer Plus Severe Sinus Congestion & Cough.

Dosages of Acetaminophen/Dextromethorphan/Phenylephrine

Dosage Forms and Strengths

Caplet

  • 325mg/10mg/5mg

Rapid Release Gelcap

  • 325mg/10mg/5mg

Capsule

  • 325mg/10mg/5mg

Oral Solution

  • (80mg/2.5mg/1.25mg)/1mL

Oral Suspension

  • (160mg/5mg/2.5mg)/5mL

Liquid

  • (325mg/10mg/5mg)/15mL

Powder for Solution

  • (650mg/20mg/10mg)/Packet

Syrup

  • (325mg/10mg/5mg)/15mL

Dosage Considerations – Should be Given as Follows:

Symptomatic Relief of Cough & Congestion

Adults and Children over 12 years:

  • 1 packet orally every 4 hours; not to exceed 6 doses/day
  • 2 caplets/capsules orally every 4 hours; not to exceed 12 caplets/capsules/day
  • 30 mL liquid/syrup orally every 4 hours; not to exceed 6 doses (12 tablespoons)/day
  • 2 gelcaps every 4 hours; not to exceed 12 gelcaps/day

Children 6-12 years old:

  • Oral suspension: 10 mL orally every 4 hours; not to exceed 50 mL/day
  • Oral solution: 4 mL orally every 4 hours as needed; not to exceed 24 mL/day

Children 4-6 years (36-47 pounds):

  • Oral suspension: 5 mL orally every 4 hours; not to exceed 25 mL/day
  • Oral solution: 2 mL orally every 4 hours as needed; not to exceed 12 mL/day

Children under 4 years old:

  • Not recommended

What Are Side Effects Associated with Using Acetaminophen/Dextromethorphan/Phenylephrine?

Common side effects of Acetaminophen/Dextromethorphan/Phenylephrine include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Acetaminophen/Dextromethorphan/Phenylephrine?

  • Severe interactions of Acetaminophen Dextromethorphan Phenylephrine include:
  • Acetaminophen/dextromethorphan/phenylephrine has serious interactions with at least 44 different drugs.
  • Acetaminophen/dextromethorphan/phenylephrine has moderate interactions with at least 232 different drugs.
  • Acetaminophen/dextromethorphan/phenylephrine has mild interactions with at least 81 different drugs.

SLIDESHOW

Cold and Flu: Finding Relief for Your Cough See Slideshow

What Are Warnings and Precautions for Acetaminophen/Dextromethorphan/Phenylephrine?

Warnings

This medication contains acetaminophen/dextromethorphan/phenylephrine. Do not take Alka-Seltzer Plus Day Cold, Theraflu Daytime Severe Cold & Cough, Tylenol Cold Multi-Symptom Daytime, Tylenol Cold Head Congestion Daytime, Vicks DayQuil Cold/Flu, Alka-Seltzer Plus Day Severe Cold, Cough & Flu, Alka-Seltzer Plus Day Sinus Congestion, Allergy & Cough, or Alka-Seltzer Plus Severe Sinus Congestion & Cough if you are allergic to acetaminophen/dextromethorphan/phenylephrine or any ingredients contained in this drug.

Contraindications

Effects of Drug Abuse

  • No information available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Acetaminophen/Dextromethorphan/Phenylephrine?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Acetaminophen/Dextromethorphan/Phenylephrine?"

Cautions

  • Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required
  • Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many over-the-counter (OTC) products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
  • Do not take dextromethorphan for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; dextromethorphan may slow the breathing
  • Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash

Pregnancy and Lactation

No information is available regarding use of acetaminophen/dextromethorphan/phenylephrine during pregnancy or while breastfeeding.

Pregnant or breastfeeding patients should seek advice of a health professional before using over-the-counter (OTC) drugs.

References
https://reference.medscape.com/drug/alka-seltzer-plus-day-cold-theraflu-daytime-severe-cold-cough-acetaminophen-dextromethorphan-phenylephrine-iv-999372

Health Solutions From Our Sponsors